Imaging-Guided Chemo–Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

Abstract

We demonstrate a versatile nanoparticle with imaging-guided chemo−photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property,

Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles

“…It should be noted that, without loading DOX, PDA-PEI@N,S-CQDs alone could already achieve a high cell mortality (90%) under 808 nm laser irradiation, and the mortality further increased after they were synergized with the DOX loading for chemotherapeutic effect. The cancer cell killing efficiency could be compared with the previous literature. ,, An in vivo study will be our next step to prove the therapeutic effect of PDA-PEI@N,S-CQDs in the practical photothermal therapy.…”

“…The cancer cell killing efficiency could be compared with the previous literature. 13,15,16 An in vivo study will be our next step to prove the therapeutic effect of PDA-PEI@N,S-CQDs in the practical photothermal therapy.…”

“…Traditional chemotherapy is one of the most effective ways to treat cancer, but it still suffers from some side effects including harming normal tissues. Therefore, it is necessary to develop a combined treatment method based on various types of therapeutic treatment, for example, chemotherapy-photodynamic therapy, − photodynamic-photothermal therapy, − chemotherapy-photothermal therapy, − etc. Among them, photothermal therapy is a very promising cancer treatment method due to low invasiveness, small side effects, and high accuracy. − Photothermal therapy generally employs near-infrared lasers to irradiate nanoparticles that reach the tumor site and light is converted to heat to thermally ablate the tumor.…”

Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

“…Appropriate surface functionalization allows CDs to fix Pt(IV)-based drugs. [199][200][201] Among surface functionalization approaches, PEGylation is commonly used. [202] The CDs platform (CDs-Pt (IV)@PEG-(PAH/DMMA)) based on cisplatin can promote the release of positively charged CDs-Pt (IV) via an electrostatic repulsion mechanism.…”

Enzyme-Responsive Materials as Carriers for Improving Photodynamic Therapy

“…Chemotherapy is one of the main treatments in the management of malignancies, but chemotherapy induced side effects have severely affected the therapeutic outcome due to non-target accumulation and drug resistance ( Xing et al, 2019 ; Jiang et al, 2020 ). In particular, the systemic toxicity of conventional chemical drugs significantly limited the development of chemotherapy ( Li et al, 2021 ). Photodynamic therapy (PDT) is being paid wide attention as a non-invasive, low-toxicity, and high-efficient treatment approach (Chi Zhang et al, 2019 ; Izumoto et al, 2020 ).…”