The amyloid precursor protein (APP) is critical in the pathogenesis of Alzheimer's disease. The question of its normal biological function in neurons, in which it is predominantly located at synapses, is still unclear. Using autaptic cultures of hippocampal neurons, we demonstrate that hippocampal neurons lacking APP show significantly enhanced amplitudes of evoked AMPA-and NMDA-receptormediated EPSCs. The size of the readily releasable synaptic vesicle pool was also increased in neurons lacking APP, whereas the release probability was not affected. In addition, the analysis of spontaneous miniature synaptic currents revealed an augmented frequency in neurons lacking APP, whereas the amplitude of miniature synaptic currents was not found to be altered. Together, these findings strongly indicate that lack of APP increases the number of functional synapses. This hypothesis is further supported by morphometric immunohistochemical analysis revealing an increase of synaptophysin-positive puncta per cultured APP knock-out neuron. In conclusion, lack of APP affects synapse formation and transmission in cultured hippocampal neurons.

At the global scale, vineyards are usually managed intensively to optimize wine production without considering possible negative impacts on biodiversity and ecosystem services (ES) such as high soil erosion rates, degradation of soil fertility or contamination of groundwater. Winegrowers regulate competition for water and nutrients between the vines and inter‐row vegetation by tilling, mulching and/or herbicide application. Strategies for more sustainable viticulture recommend maintaining vegetation cover in inter‐rows, however, there is a lack of knowledge as to what extent this less intensive inter‐row management affects biodiversity and associated ES.We performed a hierarchical meta‐analysis to quantify the effects of extensive vineyard inter‐row vegetation management in comparison to more intensive management (like soil tillage or herbicide use) on biodiversity and ES from 74 studies covering four continents and 13 wine‐producing countries.Overall, extensive vegetation management increased above‐ and below‐ground biodiversity and ecosystem service provision by 20% in comparison to intensive management. Organic management together with management without herbicides showed a stronger positive effect on ES and biodiversity provision than inter‐row soil tillage.Soil loss parameters showed the largest positive response to inter‐row vegetation cover. The second highest positive response was observed for biodiversity variables, followed by carbon sequestration, pest control and soil fertility. We found no trade‐off between grape yield and quality vs. biodiversity or other ES. Synthesis and applications. Our meta‐analysis concludes that vegetation cover in inter‐rows contributes to biodiversity conservation and provides multiple ecosystem services. However, in drier climates grape yield might decrease without irrigation and careful vegetation management. Agri‐environmental policies should therefore focus on granting subsidies for the establishment of locally adapted diverse vegetation cover in vineyard inter‐rows. Future studies should focus on analysing the combined effects of local vineyard management and landscape composition and advance research in wine‐growing regions in Asia and in the southern hemisphere.

Twelve diurnal, 9 nocturnal, and 6 intermediate species of carabid beetles common in central Europe were investigated with respect to hunting behaviour and the morphology of the head and eyes. Diurnal visual hunters are characterized by typical visually guided predatory behaviour, which consists of a turn toward the prey, followed by a jerky approach and a lunge. Nocturnal species do not react to visual stimuli but use exclusively chemical or tactile cues for orientation. Visual hunters have broader heads than the other two groups (≈ 26% of the body length as opposed to ≈ 20%), shorter antennae (≈ 45% of the body length compared with ≈ 52% in the other two groups), ≈ 50% larger eye surfaces, and, correspondingly, 50% more ommatidia per eye. The binocular overlap of the frontal visual fields of both eyes is more than 50° in visual hunters; in nocturnal and intermediate species it is usually less than 40°. Nearly all species have acute zones with small interommatidial angles in the frontolateral parts of the eye, but in visual hunters these are much more distinct. As a readily measurable indicator of the hunting behaviour and life-style of a species we describe an eye–antenna angle that is more than 60° in typical visual hunters and, in most cases, much less than 55° in nocturnal species.

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Asaphidion¯avipes, A. curtum, and A. stierlini, which are similar in shape and size, were compared for morphological measurements of the head and eyes. The species not only differ in body size but also in the relative length of their antenna, the surface area of their compound eyes, the number and density of their ommatidia, and the structure of their visual space. These differences can be interpreted functionally and correlate well with features of the various habitats in which the species are found.

Tillage is known for its adverse effects on soil biota, at least in arable agroecosystems. However, in vineyards effects might differ as tillage is often performed during dry periods or only in every other inter-row allowing species to re-colonise disturbed areas. We examined the response of earthworms (lumbricids), springtails (collembola) and litter decomposition to periodically mechanically disturbed (PMD) and permanently green covered (PGC) vineyard inter-rows and assessed whether site effects are altered by the surrounding landscape. In commercial vineyards in Austria we sampled earthworms by handsorting, springtails by soil coring and pitfall trapping and installed litter decomposition bags. Earthworm species diversity increased with plant biomass under PMD but not under PGC; earthworm density was unaffected by tillage but increased with plant biomass mainly at high soil quality (soil fertility index). Springtail species diversity was unaffected by tillage; springtail densities (mainly larger species) were reduced under PGC. Litter decomposition was little affected by investigated parameters. Landscape heterogeneity affected the functional diversity of surface springtails, but did not influence soil-dwelling springtails, earthworms or litter decomposition. We conclude that effects on soil biota of periodical tillage in vineyards need not necessarily be detrimental and will be modified by plant biomass and soil quality.

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