The objective of this study was to determine the burden of depressed mood and anxiety in COVID-19, and associated disease characteristics. Materials and Methods: This is a prospective, cross-sectional study of 114 COVID-19 positive patients diagnosed using RT-PCR-based testing over a 6-week period. The two-item Patient Health Questionnaire (PHQ-2) and the two-item Generalized Anxiety Disorder questionnaire (GAD-2) were used to measure depressed mood and anxiety level, respectively, at enrollment and for participants' baseline, pre-COVID-19 state. Severity of smell loss, loss of taste, nasal obstruction, rhinorrhea/mucus production, fever, cough, and shortness of breath (SOB) during COVID-19 were assessed. Results: PHQ-2 and GAD-2 significantly (P < .001) increased from baseline to enrollment. PHQ-2 was associated with smell loss (adjusted incidence rate ratio [aIRR]
Purpose To determine the prevalence of objective gustatory (GD) and olfactory (OD) dysfunction in COVID-19 patients. Methods This is a prospective, cross-sectional study of 51 COVID-19 positive patients diagnosed using RT-PCR-based testing. Of these study participants, 41 reported having present GD and OD at the time of enrollment and ten patients were without symptomatic OD and GD. All participants were objectively tested for OD by Brief Smell Identification Test (BSIT) and for GD by Burghart taste strip test, which were mailed to the participants. The subjective presence and severity of COVID-19 symptoms of smell loss, loss of taste, nasal obstruction, rhinorrhea/mucus production, fever, cough and shortness of breath were also assessed. Results Of the 41 patients with GD and OD, only 25.6% (10/39; p ≤ 0.0001) objectively presented GD and 39.1% (16/41; p ≤ 0.0001) OD at the time of their subjective dysfunction. Regarding GD, 23.1% (9/39) suffered from total hypogeusia, 2.6% (1/39) from ageusia. A significant loss of sour (33.3% (13/39)) and salty taste (17.9% (7/39)) could be recognized. Only 10.3% (4/39) showed a reduction in sweet and bitter taste. Concerning OD, 9.8% (4/41) showed a deficit relative to younger age in the BSIT and 29.3% (12/41) results abnormal relative to age. Conclusion Subjective and objective findings in GD and OD differ significantly. Most patients suffering from objective dysgeusia present a deficit in sour and salty taste. Trial registration number DRKS00021516; 22/04/2020.
Eine 68-jährige Patientin wurde bei seit 6 Wochen bestehender zervikaler Schwellung beidseits sowie persistierender Heiserkeit seit 50 Jahren zur weiteren Untersuchung zugewiesen. Anamnestisch war die Größe der Schwellung fluktuierend. Schmerzen, Dysphagie oder Dyspnoe sowie eine B-Symptomatik wurden verneint. Nebendiagnostisch bestanden eine COPD GOLD II, ein obstruktives Schlafapnoesyndrom, eine Adipositas Grad III und ein Foramen ovale. Zudem lag ein aktiver Nikotinabusus von 40py vor.
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