Following the 2009 update of the 2005 Framework Convention on Tobacco Control, Vietnam issued a new policy to ban smoking at workplaces and public places. This cross-sectional survey explored public attitudes toward this new regulation and provides evidence to inform future laws. Using stratified cluster sampling, 10 383 Vietnamese people older than 15 years were drawn from 11 142 selected households. Policies mandating "no smoking at workplaces" were supported by 88.7% of Vietnamese adults, whereas "no smoking in public places" and "increasing the tobacco tax" received less support. Educational level, knowledge of health effects, access to information on quitting and smoking health risks, smoking status, ethnicity, and region had significant associations with positive attitudes toward all 3 tobacco control policies. Adults belonging to the non-Kinh ethnic group, those who do not live in the Red river delta, people with lower educational levels, and current smokers should be targeted in tobacco control communication programs.

Background Clear-cell renal cell carcinomas (ccRCCs) are malignant tumors with high metastatic potential and resistance to treatments occurs almost constantly. Compared to primary tumors, there are still limited genomic data that has been obtained from metastatic samples. Methods We aimed to characterize metastatic ccRCC by way of whole-genome analyses of metastatic formalin-fixed samples, using OncoScan® technology. We identified a frequent, unexpected pL1575P NOTCH1 mutation which we set out to characterize for translational purposes. We thus implemented patient-derived xenografts from metastatic samples of human ccRCC to explore its clinical significance. Results We showed that pL1575P NOTCH1 mutation was an activating mutation, leading to the expression of NOTCH1-intracellular domain-active fragments in both cancer cells and tumor endothelial cells, suggesting a trans-differentiation of cancer cells into tumor micro-vessels. We demonstrated that this mutation could be used as a predictive biomarker of response to CB-103, a specific NOTCH1-intracellular domain inhibitor. One striking result was the considerable anti-angiogenic effect, coherent with the presence of NOTCH1 mutation in tumor micro-vessels. Conclusions We identified a frequent, unexpected pL1575P_c4724T_C NOTCH1 mutation as a new biomarker for ccRCC metastases, predictive of response to the CB103 NOTCH1-intracellular domain inhibitor.

The control of the interface and the adhesion process are key issues for the development of new application based on electrochromic materials. In this work the functionalization of an electrode’s surface through electroreduction of diazonium generated in situ from 4-(2,5-di-thiophen-2-yl-pyrrol-1-yl)-phenylamine (SNS-An) has been proposed. The synthesis of the aniline derivative SNS-An was performed and the electrografting was investigated by cyclic voltammetry on various electrodes. Then the organic thin film was fully characterized by several techniques and XPS analysis confirms the presence of an organic film based on the chemical composition of the starting monomer and allows an estimation of its thickness confirmed by AFM scratching measurements. Depending on the number of electrodeposition cycles, the thickness varies from 2 nm to 10 nm, which corresponds to a few grafted oligomers. In addition, the grafted film showed a good electrochemical stability depending on the scan rates up to 400 V/s and the electrochemical response of the modified electrode towards several redox probes showed that the attached layer acts as a conductive switch. Therefore, the electrode behaves as a barrier to electron transfer when the standard redox potential of the probe is below the layer switching potential, whereas the layer can be considered as transparent towards the electron transfer for redox probes with a redox potential above it.

Background Despite some improvement in the prognosis of metastatic clear-cell renal cell carcinoma (ccRCC), the identification of new therapeutic targets is essential. Up to now, only limited genomic data has been obtained from metastatic samples. Methods We aimed to characterize metastatic ccRCC by way of whole-genome analyses of metastatic formalin-fixed samples, using OncoScan® technology. We identified a frequent, unexpected pL1575P NOTCH1 mutation which we set out to characterize for translational purposes. We thus implemented patient-derived xenografts from metastatic samples of human ccRCC to explore its clinical significance . Results We showed that pL1575P NOTCH1 mutation was an activating mutation, leading to the expression of NOTCH1-intracellular domain-active fragments in both cancer cells and tumor endothelial cells, suggesting a trans-differentiation of cancer cells into tumor micro-vessels. We demonstrated that this mutation could be used as a predictive biomarker of response to CB-103, a specific NOTCH1-ICD inhibitor. One striking result was the considerable anti-angiogenic effect, coherent with the presence of NOTCH1 mutation in tumor micro-vessels. Conclusions We identified a frequent, unexpected pL1575P_c4724T_C NOTCH1 mutation as a new biomarker for ccRCC metastases, predictive of response to the CB103 NOTCH1-intracellular domain inhibitor. This opens the way for further clinical trials among patients with metastatic RCCs.

Background: For most infants and young children, feeding seems to be a natural process. However, only 25% of them has normal development of all all aspects and up to 80% of children with developmental problems are reported to be concerned with feeding problems. Picky eating is one of the behaviors that children with difficulty or not to accept foods. It is relatively common among infants and children, often causing anxiety for parents and caregivers. Picky eating is often linked to nutritional problems and is also the cause that parents take their child to doctor for examination and consultation. Literature review showed that there was still no unique or gold standard for defining picky eating. This study aimed to determine the method of determining picky eater in children under 5 in Hue city. Methodology: A cross-sectional study was conducted on 772 children under 5 years old and their parents or caregivers living in Hue city, Vietnam. A questionnaire was used for interviewing parents or caregivers. Picky eating was defined according to parents or caregivers’opinion and criterion of the study. 14 questions describing 3 themes of eating activities of a child was scored based on the level of difficulties, ranged from 0 to 3 points (0 for the easiest or normal and 3 for the most difficult). Three main themes included time for each meal and eating activities of the child (5 questions), number of meals, diversity and amount of food that the child consumed per day (5 questions) and emotional or behaviors of the child at mealtime (4 questions). Cronbach’s alpha was used for testing reliability of the designed scale. Using percentiles for defining cut-off point for picky eating. SPSS 20 statistics software was used to analyze data. Results: Prevalence of picky eaters based on parents or caregivers’opinion was 43.4%. The cut-off point for defining a child as picky eater (percentiles 75th) was 11. The child should be classified to be picky eater if he get 11 points and above. Using this criterion, the prevalence of picky eating should be 25.3%. Conclusions: Picky eating is common but misclassifying of parents or caregivers might higher the prevalence. Having criteria for defining picky eating and helping parents how to use it are very essential. Key words: picky eating, define, children under 5 years old

Food consumption survey is an essential parts of nutrition surveys. It helps to determine the type and quantity of food consumed, assessing the balance of the diet, the relationship between nutrient intake and health, diseases, and economic status, culture society... There are many methods to investigate food consumption. 24-hour food record is a method that record all food consumed by the subject during previous 24 hours. Using this method in chidren helps to assess the their diet to see if it responses the demand in order to have proper nutrition. Objectives: 1. Calculating the number of each food groups consumed within 24 hours of children 1 to 5 years in Phuoc Vinh ward, Hue City; 2. Assessing the quality of their diet and some related factors. Methodology: A cross-sectional study was implemented on 200 pairs of children aged 1 to 5 and parents or caregivers living in Phuoc Vinh ward, Hue city and some related factors. Results: 82% of the children’s diets covered 4 food groups. Prevalence of glucide, protein, lipide out of the total energy intake were 44.1%, 19.5%, 36.3% respectively within group of 12-<48 months and 50%, 19.5%, 30.6% respectively within group of 48-<72 months. Total energy and protein intake were higher than demanded (p <0.05) while glucide and lipide were lower than demanded (p <0.05). Economical status of family was significant associated with variety of food (all 4 food groups) in the diet of children (p <0.05) and total energy consumed (p <0.05). Conclusion: The children did not have proper nutrition so further research need to be implemented to have suitable interventions. Key words: 24 hours food records, children aged 1 to 5, Hue city.

Background: In undergraduate education, the exploitation of information and use of the Internet in teaching and learning is an indispensable requirement to serve requests renewal of teaching methods of teachers, help students actively in research , seek knowledge, and the means can be used to examine and evaluate the learning outcomes of students. Objectives: 1. Survey on the use of the internet for searching and learning of students; 2. Study the training, guidance for digital resource for students; 3. Understand the factors that affect online documentation of students. Methodology: A cross-sectional study was implemented on 346 students of general doctor from 1st to 6th year. Results: 96.2% of students using internet; 91,6% using internet at home. 79.2% of students owning mobile phones can access the internet. 15.9% of students had been guided, trained for searching online documentation. The limiting factors in finding online materials for students was that did not know how to search online documentation (49.7%), family condition (45.7%), the computer was not connected to the internet (43.4). Conclusion: Searching for online documentation is one of the most essential skills to help medical students get high results. Key words: Internet, online documentation, medical students.

Taking its shape in the 1920s of the twentieth century, existentialism has pervaded into a wide range of world literatures. In Southern Vietnam (1955 – 1975), the reception of existentialism theories underwent no crack and proved to be compatible with the social context full of volatility. Existentialism is a “humanitarian theory” (J.P.Sartre). Existentialism theories have permeated the writers’ consciousness and works in terms of their views of the human fate in the period when "God is dead”. Duong Nghiem Mau was a pioneer writer in receiving and expressing existential themes in his works, paving the way for the existential literature of Southern Vietnam. His works reflected various social aspects of life in Southern Vietnam, featuring the voice of a lost generation. The return of Duong Nghiem Mau's fiction at the beginning of the twentieth-first century emerged as a piece of evidence for the durability of existentialism and its pervasiveness in the global literature.