Editorial: Uncertainty EstimatesThe purpose of this Editorial is to discuss the importance of including uncertainty estimates in papers involving theoretical calculations of physical quantities.
Rhinoscleroma or respiratory scleroma is a chronic progressive granulomatous infection that predominantly affects the upper airways. The infection is due to a capsulate gram-negative bacterium, Klebsiella rhinoscleromatis, which was ®rst described by Von Frisch in 1882 [1]. Descriptions of the disease pre-date this considerably. The earliest evidence of rhinoscleroma comes from terracotta head-masks dated to the Mayan civilisation somewhere between 300 and 600 AD [2]. These heads showed proliferative lesions of the nose rather than the ulcerative lesions that would be more suggestive of leishmaniasis. The ®rst clear report of rhinoscleroma was in 1870 and is attributed to Von Hebra and Kaposi who considered it to be a form of sarcoma [3]. However, Mikulicz subsequently and correctly ascribed the disease to an in¯ammatory process and described the de®nitive histopathological features [4]. In 1932, at the Second International Congress of Otorhinolaryngology in Madrid, it was suggested that the name of the disease be changed from rhinoscleroma to scleroma, as it affected not just the nose but anywhere in the upper airways. However, because of possible confusion between scleroma and systemic sclerosis or scleroderma, the old name rhinoscleroma or respiratory scleroma is still preferred.
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