Applications of aerobic oxidation methods in pharmaceutical manufacturing are limited, in part, because mixtures of oxygen gas and organic solvents often create the potential for a flammable atmosphere. To address this issue, limiting oxygen concentration (LOC) values, which define the minimum partial pressure of oxygen that supports a combustible mixture, have been measured for nine commonly used organic solvents at elevated temperature and pressure. The solvents include acetic acid, N-methyl pyrrolidone, dimethyl sulfoxide, t-amyl alcohol, ethyl acetate, 2-methyltetrahydrofuran, methanol, acetonitrile, and toluene. The data obtained from these studies help define safe operating conditions for the use of oxygen with organic solvents.
Alkylphenol solvents allow a more effective production of biofuels from corn stover by enabling selective extraction and hydrogenation of levulinic acid to γ‐valerolactone, and by increasing the final concentration of GVL through successive extraction/hydrogenation steps. The versatility of alkylphenol solvents may lead to their use in other biomass conversion processes utilizing mineral acids for biomass deconstruction.
Density functional theory has been used to study the effects of solvent coordination on the structure and
formation of the titanium hydroperoxo species believed to be the active intermediate in oxidation reactions
with Ti(IV)−H2O2 catalytic systems. Titanium hydroperoxo intermediates possessing a variety of coordination
environments have been modeled with unconstrained single coordination sphere clusters using a B3LYP/ECP methodology. Titanium hydroperoxo intermediates bearing one or two solvent ligands may assume several
degenerate structures with the hydroperoxo moiety coordinated to titanium in a monodentate or bidentate
manner. Hydrogen bonding of the hydroperoxo moiety with a protic solvent ligand via a monodentate five-membered ring structure does not confer any significant additional stabilization to the titanium hydroperoxo
intermediate. The presence of a single solvent ligand on the titanium center lowers the Gibbs free energy of
activation for the formation of titanium hydroperoxo intermediates by 4−8.5 kcal/mol. Hydrogen-bonded
protic molecules can facilitate proton transfer from a hydrogen peroxide ligand on titanium and thereby lower
the Gibbs activation barrier for intermediate formation by 5−6 kcal/mol. NBO analysis provides an enriched
understanding of how solvent ligands alter structural and electronic properties and reduce activation barriers.
Consideration of thermodynamic and kinetic results indicates that the most abundant titanium hydroperoxo
intermediates formed under liquid-phase reaction conditions will most likely possess a single solvent ligand
on titanium and possibly a hydrogen-bonded protic solvent molecule.
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