Background: Iontophoresis is a technique of transferring ions into the tissues through the skin by using direct current. It can serve as a substitute for chemical enhancer, eliminates toxicity and adverse reaction formulation problems associated with chemical enhancer. Purpose: The purpose of this literature is to review the studies to see the effectiveness of Fentanyl Iontophoresis in the post operative acute pain and also to find out whether it helps in facilitating the physiotherapy in the post operative acute phase. Methods and Materials: The database literature search was carried out in the electronic database - Medline, and Research gate. Iontophoresis, Post-operative acute pain, Fentanyl Iontophoresis were the key words used to search in the electronic database. Randomized control trials, systematic review, meta-analysis, and case studies included into the review. Conclusion: Fentanyl iontophoresis system offers safety advantages in terms of opioid related drug adverse events (ORADEs) compared with morphine (iv) patient controlled analgesia for the management of acute postoperative pain. Fentanyl iontophoresis is highly potent and capable in relieving the post operative acute pain. This system of transferring ions into the tissues through the skin can play important role in initiating early physiotherapy and improve the mobility and functional limitations of the patient. Key words: Iontophoresis, Post-operative acute pain, Fentanyl Iontophoretic System.
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