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SummaryThere was I % mortality among female guppies just imported from Southeast Asia. Moribund fish showed discoloration, lethargy and kyphosis. Microscopically, myopathy and steatitis were observed, together with an extensive ceroid storage. These findings are indicative of vitamin E deficiency, and illustrate the risk of using fish of unknown origin in toxicological studies.

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Seven patients with glomerular proteinuria and hypertension (six with biopsy confirmation of glomerulonephritis, one with proteinuria after unilateral nephrectomy) were randomly given, for 14 days each, a calcium antagonist and then a conversion enzyme inhibitor, or vice versa, following a 14-day pause of all medication. Fractional albuminuria rose significantly during administration of calcium antagonists (P less than 0.05), while it decreased significantly during administration of converting enzyme inhibitor (P less than 0.05). The explanation for this finding may be that calcium antagonists raise glomerular capillary pressure by dilating the afferent arterioles, while converting enzyme inhibitors predominantly cause dilatation of the efferent arterioles.