The research was aimed to develop a set of recommendations on maintaining public health within student community. For the practical achievement of the research goal, there were studied: students' self-perceived health status and their physical and moral reaction to COVID-19; their thoughts while onlooking relatives' reaction in the conditions of self-isolation, and students' opinion on new interaction with tutors in frame of online education. This part of the research was carried out from November, 2020 till May, 2021. Respondents were the students of South region of Ukraine, who study disciplines with some risk for public health system, namely, future seafarers and medical workers. In our work we drew on theoretical and practical conclusions made by the American, European and Ukrainian researchers of public health system and of cooperation between a teacher and a student in the conditions of COVID-19 pandemic. The theoretical aspect devoted to specification of such concepts as "public health", "public health within student community", is connected with the practical one, and allows to elaborate the unique research tooling and to reflect its components during a sociological poll with the help of questionnaire analysis. Application part of work is based on an empirical social research of transformations of students' feelings and opinions under the influence of pandemic, drawing on the analysis of moral difficulties that the students of higher educational institution faced in terms of sudden and drastic change to a remote format of learning being fully separated from an educational group. Recommendations and conclusions are made by the authors in order to safeguard public health within student community.
AgEDTA complexonate was synthesized, the manner of coordination of the Argentum (I) ion to the functional groups of complexone was determined. It was found that the solid complex precipitates from the solution in the form of a fine powder. It is shown that the size and shape of nanoparticles of Argentum complexonate depend on the solvent-precipitator. A stable dispersed system based on the synthesized complexonate was obtained. The shape and position of the surface plasmon resonance bands confirm the presence of spherical nanoparticles with a size of 15–30 nm in both dispersed systems. Investigations of the biological activity of the powder of AgEDTA has shown that it has a high bactericidal effect against gram-positive bacteria.
A series of N-acyl derivatives of anthranil (or o -aminobenzoic acid) was first synthesized, namely 2-(4-octylbenzamido)benzoic acid, 2-(4-(heptyloxy)- benzamido)benzoic acid, 2-(4-(heptylsulfanyl)benz-amido)benzoic acid. 2-(4-octylbenzamido)benzoic acid was synthesized in five stages of octylbenzene, by acylating chloride acid using a Friedie-Crafts reaction. 2-(4-(heptyloxy)benzamido)benzoic acid was prepared from the methyl ester of p-hydroxybenzoic acid which, at the first stage, was activated with 1-bromoheptane in acetonitrile with potassium carbonate and catalytic amount of sodium iodide at heating. After that, hydrolysis of the ester group by hydroxide in the methanol–water system was performed. Synthesis of 2-(4-(heptylsulfanyl)benzamido)benzoic acid was carried out from p-sulfanylbenzoic acid, which was activated with 1-bromoheptane, in a system of ethanol–water with sodium hydroxide. Chlorinated hydrides of acids were obtained by reaction of acids with chlorinated thionyl in benzene. Acylation of the tret-butyl ester of anthranilic acid with formed chlorohydrides was carried out in pyridine upon heating and in dichloromethane with triethylamine (as the base), and dimethylaminopyridine (catalyst).At the last stage of the synthesis of all derivatives, the hydrolysis of tret-butyl esters with trifluoroacetic acid in dichloromethane to the formation of terminal compounds took place.The composition and structure of the synthesized compounds were determined using NMR 1H, infrared spectroscopy. The shape and position of the bands in the IR absorption spectra of the synthesized anthranilic acid derivatives are shifted and splited in comparison with the parent acid due to the presence of a secondary amino group, an additional aromatic moiety, and a different nature of the substitutes in the para-position to the amino group. For all synthesized derivatives, the sensitivity of various morphological forms Candida albicans was determined. The influence of the test substances on the cells of the yeast fungus was determined for 24–48 hours using Saburo and Spider nutrient media with the addition of mannitol. Compared with the already known influence of anthranilic acid on Candida albicans cells grown in Saburo nutrient medium for 24 hours, the compounds studied were more effective at all stages of cultivation. It has been shown that the synthetic derivatives studied are more active with respect to the cells in the biofilm composition, which consists of the yeast-like form of Candida albicans, than those cells that form a hyphal type biofilm. The yeast-like form of the Candida albicans cell is susceptible to synthetic derivatives. It is shown that the level of sensitivity of compounds 1-3 is higher in 4-6 times compared with anthranilic acid. Glyphs have been found to be more susceptible to the effects of the compounds studied than Е yeast cells of Candida albicans
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