We suspected that in each day-care center that there was one prevailing viral strain. We suppose that CMV infections were acquired inside the day-care centres. This is a first report which described viral transmission in day-care centres in Japan.

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N microorganisms, a single mutation event can result in the growth require-' ment of two amino acids, isoleucine and valine. This is not considered unusual since the two amino acids share a common biosynthetic pathway (UMBARGER and DAVIS 1962), (Figure 1). In Salmonella typhimurium (GLANVILLE and DEMEREC 1960), the genes controlling the synthesis of the enzymes of the isoleucine-valine pathway are clustered in a short region of chromosome. On the other hand, the genes of Neurospora crassa ( KIRITANI 1962;WAGNER, BERGQUIST, BARBEE and KIRITANI 1964) and Saccharomyces cerevisiae (KAKAR and WAGNER 1964) that control the production of similar enzymes are not clustered in any one region of a chromosome. The finding of what may be organizational mutants in Neurospora (WAGNER, KIRITANI and BERGQUIST 1962) and Saccharomyces (KAKAR and WAGNER 1964) provides a clue with which one can analyze the relationship between the cytoplasmic organization of enzymes of the biosynthetic pathway and the location of the genes controlling these enzymes. A study of the

Generalized resistance to thyroid hormone (GRTH), or Refetoff syndrome, is a disease in which peripheral tissues show resistance to thyroid hormone. Three patients with this disease were investigated. Cases 1 and 2 involved identical 7-year-old female twins and case 3, a 5-year-old girl. AU three patients had goiters, and cases 1 and 2 had sensorineural deafness. In all three, the blood levels of T4, free T4, and T3 were high, while the blood levels of TSH were normal or slightly elevated. The responses shown by blood levels of the thyroid hormone and TSH to administration of propylthiouracil and T3 suggest that the regulating mechanism in the hypothalamic-pituitary-thyroid system was functional. Upon administration of T3, no sign of hyperthyroidism was observed.(Acta Paediatr Jpn 1989; 3 1 : 7 12 -720)

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