The Fc receptor (FcR) on human lymphocytes is studied by using soluble immune complexes in antigen excess, prepared between ferritin and rabbit anti-ferritin, and a modification of Coombs’ antiglobulin reaction (double-coating indirect rosette formation). 12% of human blood lymphocytes are shown to have Fc receptors. The FcR on lymphocytes is sensitive to pronase treatment, partially sensitive to trypsin digestion, and is inactivated after short glutaraldehyde fixation of lymphocytes. By cell fractionation experiments, FcR-positive lymphocytes were enriched in cell populations enriched with B cells.
Magnetic resonance imaging (MRI) of the knee articular cartilage is possible owing to the contrast provided by different signal intensities of adjacent menisci and subchondral bone. The objective of this study was to determine the accuracy of MRI in quantitatively detecting thinning and focal defects of articular cartilage in vivo. High resolution MRI was performed foliowed by dissection of the knee within one hour of amputations above the knee of eight patients (62-89 years) with peripheral vascular disease. Table 1 gives details of the patients studied.Magnetic resonance imaging was performed on extended knee joints obtained within one hour of amputations above the knee in eight patients with peripheral vascular disease. High resolution, TI weighted, spin echo coronal and sagittal images were obtained with a 256x256 matrix in a field of view of 24 cm (0-95 mm/pixel) in either a 1 0 tesla (five knees) or a 15 tesla (three knees) Siemen's instrument using opposed surface coils in a Helmholtz configuration as the receiver. Repetition time (TR) was 600 or 700 ms and echo time (TE) was 22 or 17 ms, respectively. Multiple sagittal images 3 mm thick were obtained with a gap of 15 mm-that is, at 4-5 mm intervals. The frequency encoding axis was perpendicular to the articular cartilage on the tibial plateau. Chemical shift artefact-that is, overlap of signals from the marrow fat-was not sufficient to interfere with visualisation of the tibial or femoral articular cartilage because the thickness of subchondral bone (which has very low signal) separated the fatty marrow from the articular cartilage.In our experience T1 weighted images produced the best contrast between subchondral bone, articular cartilage, and the menisci, and therefore only TI weighted images were used for the analysis of articular cartilage thicknesses.Window settings were adjusted to optimise the contrast between articular cartilage and subchondral bone or meniscal cartilage. It should be emphasised that window settings optimised for this purpose are not necessarily the best for obtaining a good photographic reproduction, and thus the quality of the original magnetic
A case is reported of a patient who developed a histologically unusual sarcoma in the axilla and chest wall 8 years after receiving radiation therapy (6500 rad) for carcinoma of the breast. This sarcoma showed light-and electronmicroscopic features of a malignant fibrous histiocytoma, a tumor not documented among 24 previously reported cases of postirradiation sarcoma following the diagnosis of breast carcinoma. In addition, the literature is reviewed and discussed regarding postirradiation sarcoma in general following breast carcinoma.Cancer 42:118-124, 1978.
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