Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis

Fernandez-Madrid, Felix; Karvonen, Robert L.; Teitge, Robert A.; Miller, Peter; An, Teisa; Negendank, William

doi:10.1016/0730-725x(94)00119-n

Cited by 181 publications

(120 citation statements)

References 14 publications

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“…The importance of synovitis in OA progression is well recognized 32e36 . OA knee joints usually show signs of synovitis, even in the early stage of the disease 37,38 . MR imaging in patients who either have or are at risk for knee OA showed that high-grade synovitis was associated with knee pain compared with those with no or lowgrade synovitis 39,40 .…”

Section: Discussionmentioning

confidence: 99%

Pain in patients with equal radiographic grades of osteoarthritis in both knees: the value of gray scale ultrasound

Shao

et al. 2012

Osteoarthritis and Cartilage

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s u m m a r yObjectives: To investigate the association of ultrasound (US) features with pain and the functional scores in patients with equal radiographic grades of osteoarthritis (OA) in both knees. Methods: Fifty-six consecutive patients with knee OA: 85 symptomatic knees (81 knees with medial pain) and 27 asymptomatic knees, and 10 healthy patients without knee OA as a control were enrolled. US was done by two ultrasonographers blinded to patient diagnoses. US features were semiquantitatively scored (0e3) when appropriate. Results: In the OA group, common US findings were marginal osteophyte, suprapatellar synovitis, suprapatellar effusion (SPE), medial meniscus protrusion, medial compartment synovitis (MCS), lateral compartment synovitis, and Baker's cyst. Only SPE and MCS were significantly associated with knee pain. Visual analog pain scale (VAS) scores on motion were positively linearly associated with SPE and MCS (P < 0.01). Only MCS was degree-dependently associated with VAS scores at rest, the Western Ontario and McMaster Universities pain subscale, and the presence of medial knee pain (P < 0.01) after adjustments for age, gender, body mass index (BMI), radiographic grade, and other US features. In the control group, no US features were associated with knee pain. Conclusions: US inflammation features, including SPE and MCS, were positively linearly associated with knee pain in motion. MCS was also degree-dependently associated with pain at rest and the presence of medial knee pain. These findings show that synovitis was one important predictive factor of pain. Further studies to confirm the association of US features and pain are warranted.

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Section: Discussionmentioning

confidence: 99%

Pain in patients with equal radiographic grades of osteoarthritis in both knees: the value of gray scale ultrasound

Shao

et al. 2012

Osteoarthritis and Cartilage

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“…Although present in low numbers, B cells and plasma cells were detected in OA ST 8,9,11,29,34,35,44 . However, their relative abundance is lower than in RA 44 .…”

Section: B Cellsmentioning

confidence: 97%

“…Several authors reported that macrophages and T cells are the most abundant cells 8,9,11,17,20,21,25,34,35,37,45,47,48,51,56,57,61,62,69,78 . Mast cells (MCs) 49,50,54,55,58e60,64,67,70,79 , as well as B cells and plasma cells were found, although the last two in lower amounts than other cells 9,11,21,24,25,33e35,44,45,57,69,73 .…”

mentioning

confidence: 99%

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

Lange-Brokaar

Ioan‐Facsinay

Osch

et al. 2012

Osteoarthritis and Cartilage

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“…In a human data series, some degree of synovial thickening was found in a majority of osteoarthritic joints (Fernandez-Madrid et al 1995). Whether this synovitis contributes directly to articular cartilage loss in OA, or simply arises in reaction to the breakdown of cartilage, remains unclear.…”

Section: Synovitis and Joint Effusionsmentioning

confidence: 99%

In vivo magnetic resonance imaging of animal models of knee osteoarthritis

Wáng

2008

Lab Anim

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SummaryRecent technical developments in high-field magnetic resonance (MR) scanners, improvement in radio frequency coil design and gradient performance along with the development of efficient pulse sequences and new methods of enhancing contrast have made high-quality imaging of animal arthritis models feasible. MR can provide high-resolution structural information about the osteoarthritic changes in animal models, and also information about the biophysical properties of cartilage. This paper reviews the MR techniques available for animal knee imaging, and the various MR-derived readouts of knee osteoarthritis in animal models. Pitfalls in interpreting animal joint anatomy and joint composition are highlighted.

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Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis

Cited by 181 publications

References 14 publications

Pain in patients with equal radiographic grades of osteoarthritis in both knees: the value of gray scale ultrasound

Pain in patients with equal radiographic grades of osteoarthritis in both knees: the value of gray scale ultrasound

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

In vivo magnetic resonance imaging of animal models of knee osteoarthritis

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