The bactericidal potency of ozone was examined for exploring the potential of dental application of ozone gel. Treatment with10 ppm ozone gel with quenching after 3 h and treatment with 100-ppm ozone gel with immediate quenching showed antimicrobial effects in eight aerobic strains, namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Methicillin-resistant S. aureus (MRSA), S. epidermidis, Klebsiella pneumoniae, and Streptococcus mutans. For five of these strains (E. coli, P. aeruginosa, C. albicans, K. pneumoniae, and S. mutans), the number of colony forming units (CFUs) were below the detection limit after treatment with 10 ppm ozone gel with quenching after 3 h. For Bacillus subtilis, an antimicrobial effect was observed after 3 h of treatment with 100 ppm of ozone gel. In the case of anaerobic bacteria, bactericidal effect was observed for five strains, namely, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Eikenella corrodens, by using ozone gel and ozone cream. Of these, the number of CFUs for three strains (P. gingivalis, P. intermedia, and F. nucleatum) was below the detection limit. These results suggest that the ozone gel can be clinically useful in oral surgery for implant treatment because of its instantaneous antimicrobial effects, and that it can be used against a variety of bacterial strains.
Ozone is a potent oxidative gas and its bactericidal effect is exploited in dental practice. However, the half-life of ozone is extremely short, which limits its ability to exert bactericidal effects on cells. Therefore, we focused on ozone gel, which is composed of a glycerin solution containing ozone, a recently developed technology, in vivo. In the course of our study, we evaluated the safety of ozone gel application to the skin and eye, as well as its effects on hemostasis and antimicrobial effects. In this study, we found that ozone gel was nontoxic to the oral mucosa. Our results suggest that ozone gel represents a clinically agent for periodontal diseases and peri-implant diseases.
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