The benefit and efficacy of ketepeng cina (Senna alata) in the treatment of infection has shown that have antibacterial activity, inhibiting and killing bacteria that cause infection. The objective of this study was evaluate the antibacterial activity of ketepeng cina against Staphylococcus aureus dan Escherichia coli in vitro. This study was a laboratory experimental research which use completely randomized design with diffusion method. Ethanol extract of Senna alata leaves devided into 4 doses, i.c. 100, 50, 25 and 12.5. Amoxiclave were used as positive control and aquadest negative control. The data were analyzed by Analysis of Varian continued with Duncan's Multiple Range Test. The result of this study showed that antimicrobial activity of ethanol extract Senna alata leaves inhibited the growth of Staphylococcus aureus, but not Escherichia coli. The optimum effect was showed given by the concentration 100 at 17.7 mm.
Uninary tract infection (UTI) is a common health problem among the people in the world, including Indonesia.Approximately 80% of UTI in hospital are ascociated with urethral catheter used in hospitalized patients. The increaseof catheter- related UTI is olso followed by increase of antibiotic used. The diffrence in distribution of UTI causingbacteria and antibiotics resistance associated with cathetetization can change according to time and place. This stdyaims to find the pattern of antibiotic resistance in the urine of catheter related UTI patient. The research was done inDepartement of Internal Medicine RSUD arifin Achmad Pekanbaru. 31 samples were collected from hospitalizedpatient who used catheter at last 3 days and taken with indwelling catheter urine. Culture, colony count, colonyidentification and resistance test was performed by Kirby Bauer method. The result was interpretated based onClinical and Laboratory Standard Institude (CLSI). UTI found in 19 samples (61.29%), 9 samples founs no bacteria(29.03%) and Candida albicans on 3 samples (9.68%). UTI caused mostly by Gram-negative bacteria (57.89%),Gram- positive bacteria found in 42.11% of samples. The highest resistance (100%) was found on cefotaxim, cefriaxon,cefalexin and tertracyclin. The lowest resistance (73.68%) found on merofenem and co-trimoxazole.
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