Celiac disease (CD) is characterized by clinical polymorphism, with classic, asymptomatic or oligosymptomatic, and extra-intestinal forms, which may lead to diagnostic delay and exposure to serious complications. CD is a multidisciplinary health concern involving general medicine, pediatric, and adult gastroenterology, among other disciplines. Immunology and pathology laboratories have a fundamental role in diagnosing and monitoring CD. The diagnosis consists of serological testing based on IgA anti-transglutaminase (TG2) antibodies combined with IgA quantification to rule out IgA deficiency, a potential misleading factor of CD diagnosis. Positive TG2 serology should be corroborated by anti-endomysium antibody testing before considering an intestinal biopsy. Owing to multiple differential diagnoses, celiac disease cannot be confirmed based on serological positivity alone, nor on isolated villous atrophy. In children with classical signs or even when asymptomatic, with high levels of CD-linked markers and positive HLA DQ2 and/or DQ8 molecules, the current trend is to confirm the diagnosis on basis of the non-systematic use of the biopsy, which remains obligatory in adults. The main challenge in managing CD is the implementation and compliance with a gluten-free diet (GFD). This explains the key role of the dietitian and the active participation of patients and their families throughout the disease-management process. The presence of the gluten in several forms of medicine requires the sensitization of physicians when prescribing, and particularly when dispensing gluten-containing formulations by pharmacists. This underlines the importance of the contribution of the pharmacist in the care of patients with CD within the framework of close collaboration with physicians and nutritionists.

Introduction The SARS-CoV-2 pandemic has had a considerable impact, causing millions of deaths worldwide, including many healthcare workers (HCWs). The pharmaceutical industry has been working diligently since the start of the pandemic to develop various vaccines to fight the spread of the virus and protect the population. Objective To study the seroprevalence of neutralizing anti-SARS-CoV-2 antibodies in vaccinated HCWs at the Mohamed VI University Hospital in Marrakech and to determine the parameters that can influence immune response. Methods A cross-sectional study of 138 HCWs was performed between October and December 2021 by measuring IgG antibodies directed against the spike antigen of SARS-CoV-2 using an Abbott Architect® SARS-CoV-2 IgG II assay. Results The mean age was 31.42 years, the sex ratio was 2.94 women to each man, and the overall prevalence was 97%. We found 39.5% of the participants had experienced COVID-19 infections pre-vaccination, which decreased to 26.8% after vaccination. Neutralizing antibody titers were dependent on the type of vaccine: they were higher with the Pfizer-BioNTech vaccine, the number of doses ( p < .001), and post-vaccine COVID-19 form. The post-vaccine COVID-19 infection rates were lower with the Sinopharm vaccine. Conclusion Heterologous vaccination with non-mRNA and mRNA vaccines and the consideration of post-vaccination COVID-19 infection as a booster could help optimize vaccine results while reducing potential side effects.

Since the beginning of the COVID-19 pandemic, many cases of SARS-CoV-2 co-infection with other respiratory pathogens have been reported. These situations may be a source of under-diagnosis leading to the spread of SARS-COV-2. We report the first case of triple infection involving SARS-CoV-2, Adenovirus and Respiratory Syncytial Virus in 4 months old infant. Initially admitted with symptoms of viral bronchiolitis. The aim is to highlight the importance of using multiplex PCR for the syndromic approach of respiratory infections in this pandemic period, especially in children, in order to limit spread of COVID-19 to others.

Coronavirus disease 2019 (COVID-19) is an emerging infection that has caused a pandemic, it is due to a virus of the coronavirus family called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which can evolve into severe forms leading to death. Several biochemical alterations have been described in COVID-19 patients with great significance for clinical diagnosis and outcome prediction. The aim of this study is to compare early evolution of biochemical disturbances in COVID-19 patients and correlate them to severity of the disease. This study was conducted in 70 COVID-19 patients hospitalized at the Avicenna military hospital. 20 patients in the medical intensive care unit (severe group) and 50 patients in the COVID-19 isolation hospital (non-severe group). Across our laboratory data analysis of the two groups of COVID-19 patients, we demonstrated that high titles and early elevation of ferretinemia, Interleukin-6, High-Sensitivity Troponin T(us), NT-Pro-BNP, Blood Urea nitrogen, Creatinine and LDH are significantly correlated to severity of the disease. The analysis of this study through the recent scientific literature demonstrates the interest of early monitoring of biochemical markers in the diagnosis of severity and monitoring of severe forms of covid-19.