2021
DOI: 10.1177/20587384211008709
|View full text |Cite
|
Sign up to set email alerts
|

Celiac disease: Understandings in diagnostic, nutritional, and medicinal aspects

Abstract: Celiac disease (CD) is characterized by clinical polymorphism, with classic, asymptomatic or oligosymptomatic, and extra-intestinal forms, which may lead to diagnostic delay and exposure to serious complications. CD is a multidisciplinary health concern involving general medicine, pediatric, and adult gastroenterology, among other disciplines. Immunology and pathology laboratories have a fundamental role in diagnosing and monitoring CD. The diagnosis consists of serological testing based on IgA anti-transgluta… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
19
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 17 publications
(19 citation statements)
references
References 102 publications
0
19
0
Order By: Relevance
“…A positive diagnosis of CD can be achieved through a combination of clinical parameters, immunological parameters (positive serological levels for total IgA and IgA anti-intestinal transglutaminase 2 antibodies (TGA-IgA), IgA anti-endomysium antibodies (EMA-IgA) and IgG deamidated gliadin peptide (DGP) antibodies (DGP-IgG) and/or histological data, obtained by biopsy; in clinical practice, the serologic IgA tissue transglutaminase antibodies have a sensitivity close to 97%, while EMA-IgA antibodies are highly specific markers (approximately 100%) for CD diagnosis [ 67 , 68 , 69 , 70 , 71 , 72 , 73 ].…”
Section: Celiac Disease In Children—general Aspectsmentioning
confidence: 99%
“…A positive diagnosis of CD can be achieved through a combination of clinical parameters, immunological parameters (positive serological levels for total IgA and IgA anti-intestinal transglutaminase 2 antibodies (TGA-IgA), IgA anti-endomysium antibodies (EMA-IgA) and IgG deamidated gliadin peptide (DGP) antibodies (DGP-IgG) and/or histological data, obtained by biopsy; in clinical practice, the serologic IgA tissue transglutaminase antibodies have a sensitivity close to 97%, while EMA-IgA antibodies are highly specific markers (approximately 100%) for CD diagnosis [ 67 , 68 , 69 , 70 , 71 , 72 , 73 ].…”
Section: Celiac Disease In Children—general Aspectsmentioning
confidence: 99%
“…Such an assessment would enable the dietitian to recognize and help patients overcome any nutritional excess or deficiency observed at each consultation. 4 This can be completed through a 24-hour dietary recall and/or a 3-, 5-, or 7-day food record, or through a food frequency questionnaire. 48 The latter method must be validated and adopted in each country, taking into account the nutritional value of gluten-free foods.…”
Section: Nutritional Status Of Patients With CD Following a Gfdmentioning
confidence: 99%
“…3 The diagnosis of CD is based upon serological testing and duodenal biopsy. 4 The prevalence of CD in the general population varies between 0.7% and 1.4%. 5 The disease remains almost unknown in Southeast Asia and sub-Saharan Africa, but common in North Africa, in the Middle East and India, with a prevalence similar to that of Europe or the United States.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…The diagnostic difficulties are partly due to the wide spectrum of the possible manifestations of the disease. In recent years, there has been a shift in the clinical presentation of CD from the classical form to the non-classical, oligosymptomatic, and asymptomatic forms [ 3 , 5 ]. Riznik et al [ 3 ] carried out a study enrolling 653 children and adolescents with CD from different European countries showing that the age at diagnosis of CD has increased during the past decades with an actual median age of 7 years.…”
Section: Introductionmentioning
confidence: 99%