Coronavirus disease 2019 (COVID-19) is an emerging infection that has caused a pandemic, it is due to a virus of the coronavirus family called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which can evolve into severe forms leading to death. Several biochemical alterations have been described in COVID-19 patients with great significance for clinical diagnosis and outcome prediction. The aim of this study is to compare early evolution of biochemical disturbances in COVID-19 patients and correlate them to severity of the disease. This study was conducted in 70 COVID-19 patients hospitalized at the Avicenna military hospital. 20 patients in the medical intensive care unit (severe group) and 50 patients in the COVID-19 isolation hospital (non-severe group). Across our laboratory data analysis of the two groups of COVID-19 patients, we demonstrated that high titles and early elevation of ferretinemia, Interleukin-6, High-Sensitivity Troponin T(us), NT-Pro-BNP, Blood Urea nitrogen, Creatinine and LDH are significantly correlated to severity of the disease. The analysis of this study through the recent scientific literature demonstrates the interest of early monitoring of biochemical markers in the diagnosis of severity and monitoring of severe forms of covid-19.
Chronic suppurative otitis media (CSOM) is a perforated tympanic membrane with persistent drainage from the middle ear. It is an avoidable cause of hearing loss, especially in developing countries. We conducted a prospective study over 8 years (1 January 2014 - 1 January 2022), Including 250 patients consulting the Oto-Rhino-Laryngology Department of the Avicenna Military Hospital in Marrakesh, in collaboration with the Laboratory of Microbiology. It included all non-redundant bacterial species isolated from pus of purulent chronic ear infections sent to the microbiology laboratory. The cytobacteriological analysis was carried out according to the conventional techniques and / or automated method of BD PhoenixTM. The antibiotic sensitivity study was carried using the diffusion method in agar medium according to the recommendations of the CA-SFM. There were 147 men and 103 women with a sex ratio of 1.4. The mean age of the patients was 34 years (8 to 82 years). The second and fourth decades represent the most affected age groups. The bacteriological profile was dominated by Pseudomonas aeruginosa (40%), followed by Staphylococcus aureus (32%) and Proteus mirabilis (13%). These different isolates represented low antibiotic resistance levels but all remained sensitive to fluoroquinolones. Five strains of enterobacteria produced derepressed cephalosporinase, and nine strains of Enterobacteria carrying extended spectrum Beta lactamase enzymes. No strain of Pseudomonas resistant to ceftazidime was isolated. Gram positive cocci accounted for 38% of the strains. In view of the bacteriological and the sensitivity profiles of the species found in chronic otitis, antibiotics based on fluoroquinolones are recommended.
Viral hepatitis B (HBV) is a major public health problem worldwide. Indeed, the World Health Organization (WHO) estimates that more than 2 billion the number of people who have been exposed to this virus, about 30% of the world population, 18% in sub-Saharan Africa and 41% in Asia, of which 5% with chronic infection or 300-350 million. So the HBV prevalence is 5.4% globally, against 1% for the HIV and 3% for hepatitis C. More than 1 million of them die each year complications essentially cirrhosis and hepatocellular carcinoma. The diagnostic of HBV (recent or chronic infection) relies on research HBs antigen in the serum of patients, it is the witness of a recent or past infection with HBV according to the presence or absence of other serological markers (HBe Ag, anti-HBs Ig and total anti-HBc and anti-HBe antibody IgM) but they do not provide information on the status of viral replication. The detection and quantification of HBV genome (replication of viral marker) can be performed in serum, liver tissue or in blood mononuclear cells. They typically based amplification methods: Polymerase Chain Reaction (PCR). The treatment of viral hepatitis B is for patients with hepatitis B associated with viral replication (HBV DNA positive), cytolysis (elevated transaminases) and presence on biopsy of an activity necroinflammatory or significant fibrosis. Despite the recent antiviral therapeutics, treatment of chronic hepatitis B is difficult and expensive, and the prevention of HBV infection through routine immunization policy and prevention measures currently remains the best option for reducing morbidity and mortality from liver failure and liver cancer. Morocco is considered far, according to WHO data, such as having an intermediate prevalence of viral hepatitis B. Currently, few studies relate the epidemiology of hepatitis B (HBV) in Morocco. The objective of this study was the evaluation of the HBV infection prevalence in a Moroccan workers population, and compare with national and international studies. A total of 20192 individuals were screened for HBsAg. HBV screening was conducted by immunoassay chemiluminescent micro particle (CMIA) PLC (Abbott Architect) and with a prevalence rate of HBsAg estimated at 0.55%. These data are of interest for the diagnosis and prognosis, and therapeutic decision, and can be for the development of an eventual national strategy for the prevention of the transmission of HBV.
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