To evaluate immunohistochemical p16 expression and its prognostic utility in tongue SCC in two geographically and ethnically distinct populations. Methods: 88 patients from the Sydney Head and Neck Cancer Institute and 44 patients from the National Cancer Centre Singapore with tongue SCC were identified from 2001 to 2012. p16 immunohistochemistry was performed. Strong nuclear and cytoplasmic staining in more than 70% of cells was interpreted as positive. Clinicopathologic data were obtained. Results: p16 expression was seen in 18% (16) of Australian and 23% (10) of Singaporean cases. The study populations showed no significant demographic differences. The Australian cohort had a significantly higher number of poorly differentiated cases (p=0.034), however no significant differences were observed in other histopathological features such as depth of invasion, lymphovascular and perineural invasion, or pTNM staging. The majority of p16 positive cases in both cohorts were early pT stage tumours, with pN0 nodal status. p16 negative cases were more likely to receive post-operative radiotherapy in both cohorts. The interaction between p16 expression and institution was not significantly associated with overall survival. Conclusion: Rates of p16 expression are similar between both study populations. The effect of p16 expression on overall survival did not vary according to the institution. 115. AN INTEROBSERVER REPRODUCIBILITY ANALYSIS OF KI67 VISUAL ASSESSMENT IN BREAST CANCER
Primary effusion lymphoma (PEL) is an aggressive neoplasm with a high rate of fatality. PEL cells are known to have morphological diversities, which range from immunoblastic or plasmablastic to anaplastic. Most of these cases are described in immunocompromised as well as immunocompetent patients. Plasmablastic lymphoma remains a diagnostic challenge, especially when encountered with the presentation as PEL. In spite of therapeutic advances, PEL remains an aggressive disease with a high rate of fatality. We describe one case of this extremely rare neoplasm in an immunocompromised patient presenting in the form of primary central nervous system effusion plasmablastic lymphoma. To the best of our knowledge, this is the first case ever been reported in the literature.
To determine the cause for massive splenomegaly. MATERIALS AND METHODS: Splenectomy was done and sections given from cut surface. They were stained with haemotoxylin & eosin and microscopically analysed. Immunohistochemical study was done for a panel of antibodies including CD5, CD10, CD20, bcl-2 & cyclin D1. RESULTS: Microscopy showed effacement of the normal architecture along with a nodular architecture in the white pulp with small lymphocytes surrounded by medium to large lymphoid cells with dispersed chromatin and abundant pale cytoplasm which resembled the marginal zone cells. Immunohistochemical study showed positivity for CD20 and bcl-2. It was negative for CD5, CD10 and Cyclin D1. Considering all the findings a diagnosis of Splenic Marginal Zone Lymphoma (SMZL) was made. CONCLUSION: In this case, clinically lymphoma was not suspected, as splenomegaly was the only finding. Patient was thoroughly investigated for various causes of splenomegaly but only histopathological evaluation of spleen along with IHC study was diagnostic.
Introduction:Cervical carcinoma is one of the leading causes of death among women worldwide. An estimated of 2,30,000 women die annually from cervical cancer, and almost 1,90,000 are from developing countries. It is considered to be the 3rd most common malignancy among women. Materials and Methods: This is a 5 year retrospective study done in the department of pathology, Kasturba medical college, Manipal. Hysterectomy and cervical biopsies are included in this study. Clinical details were obtained from case sheets. Results: 175 cases of cervical neoplasms were studied in total. The patient's age was ranged 21 to 80 years with mean being 50.5 years. Among the commonest complaints was post-menopausal bleeding followed by menorrhagia and intermenstrual spotting. 49% cases had a growth in the cervix followed by 12% cases with induration and 10% cases as polyp in cervix. Among the 175 cases, 14.86% cases were precursor lesions. Among the malignant cases, squamous cell carcinomas (61.71%) were the commonest. Rare tumour includes 2.86% cases of minimally invasive carcinoma, 1.71% cases of neuroendocrine carcinoma, and 1.14% cases each of serous carcinoma. Conclusion: Neoplastic lesions from the uterine cervix comprise of a wide variety of lesions originating from both the epithelial and stromal elements. Among the malignant tumours, squamous cell carcinoma was very common. Hence, a thorough clinical evaluation and post-menopausal health check-ups along with detailed cervical examination and microscopic evaluation is the key towards correct and timely diagnosis of cervical neoplasms.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.