Primary splenic marginal zone lymphoma: A case report

Abstract

To evaluate immunohistochemical p16 expression and its prognostic utility in tongue SCC in two geographically and ethnically distinct populations. Methods: 88 patients from the Sydney Head and Neck Cancer Institute and 44 patients from the National Cancer Centre Singapore with tongue SCC were identified from 2001 to 2012. p16 immunohistochemistry was performed. Strong nuclear and cytoplasmic staining in more than 70% of cells was interpreted as positive. Clinicopathologic data were obtained. Results: p16 expression was seen in 18% (16) of Australian and 23% (10) of Singaporean cases. The study populations showed no significant demographic differences. The Australian cohort had a significantly higher number of poorly differentiated cases (p=0.034), however no significant differences were observed in other histopathological features such as depth of invasion, lymphovascular and perineural invasion, or pTNM staging. The majority of p16 positive cases in both cohorts were early pT stage tumours, with pN0 nodal status. p16 negative cases were more likely to receive post-operative radiotherapy in both cohorts. The interaction between p16 expression and institution was not significantly associated with overall survival. Conclusion: Rates of p16 expression are similar between both study populations. The effect of p16 expression on overall survival did not vary according to the institution. 115. AN INTEROBSERVER REPRODUCIBILITY ANALYSIS OF KI67 VISUAL ASSESSMENT IN BREAST CANCER