No abstract

The aim of this study is to evaluate four drug regimens for treatment of scabies as regard their efficacy, acceptability and cost effectiveness. Two hundred cases with ordinary scabies were randomized into four groups. First group received ivermectin 200 μg/kg body weight single oral dose, repeated after one week. The second received benzyl benzoate 20% cream. The third received permethrin 2.5%-5% lotion, whereas the fourth group received 5-10% sulfur ointment. Topical treatments were applied for five consecutive nights. Patients were followed up for two weeks for cure rate and adverse effects. At the end of the study, permethrin provided a significant efficacy of 88% and acceptability in 100% of cases, but had higher cost to treat one case (20.25 LE). Ivermectin provided efficacy and acceptability rates of 84% and 96%, respectively, and had a cheaper cost (9.5 LE). Benzyl benzoate provided 80% for both rates and was the cheapest drug. Sulfur ointment provided the least rates, and it was the most expensive. Treatment choice will depend on the age, the general condition of cases, patient compliance to topical treatment and his ability to stick to its roles, and the economic condition of the patient.

Multiple sessions are effective in rejuvenation of the aging face with high safety, short downtime, and no adverse effects. They stimulated formation of new collagen (type I, III, and VII) up to 6 months after treatment with better improvement in skin texture and fine wrinkles. The variable number of fractional Er:YAG laser sessions (3-5) showed no significant difference as regards efficacy.

Scar sarcoidosis is one of the rare cutaneous manifestations of sarcoidosis. Apart from the clinical picture, suppression of the cell-mediated immunity can often be determined when tuberculin tests and testing for recall antigens are carried out. In the present case of a 68-year-old woman patient scar sarcoidosis and pulmonary sarcoidosis were detected. Remarkably, a strongly positive tuberculin reaction was found, while acute tuberculosis and former BCG vaccination were excluded. Both references in the literature and the case presented demonstrate that a positive tuberculin test, while very unusual in sarcoidosis, does not however, preclude the diagnosis. On the basis of some case reports in the literature, our patient was treated with allopurinol; impressive improvement of both the skin and the pulmonary manifestations was noted. Despite the well-known phenomenon of spontaneous regression in sarcoidosis, we recommend a clinical trial with allopurinol as this substance is well tolerated.

Background: Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Aim of the work: To compare the efficacy of topical calcipotriol versus oral vitamin D in alopecia areata. Patient and Methods: Fifty patients having localized alopecia (<5 patches and <40% scalp involvement) were treated with topical calcipotriol 0.005% twice daily for 3 months (group 1) and oral vitamin D daily for 3 months (group 2). All cases were assessed by grading the degree of improvement of alopecia and dermoscopic evaluation. Estimation of serum levels of 25-hydroxy vitamin D in all patients before the treatment. Results: There was statistically significant difference with p-value < 0.05 between two study groups regarding to degree of improvement. Dermoscopic findings that explain signs of activity were decreased, and signs of improvement were appeared after 3rd months of treatment. In topical calcipotriol group terminal hair was more than oral vitamin D group, in which signs of activity was still present in some cases. Conclusion: In conclusion, topical calcipotriol (68% improvement) was better than oral vitamin D in the treatment of mild and moderate alopecia areata. There is no releation between serum vitamin D and efficacy of treatment. However, further studies on larger scales are required to identify the vitamin D receptor deficiency in alopecia areata.

<div class="Section1"><p class="abstract"><strong>Background:</strong> Acne vulgaris is a multifactorial skin disease. A potential role for insulin-like growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1 correlate with overproduction of sebum and acne. Objective: Measurement of the serum level of IGF-1 in acne patients in comparison to normal controls and evaluating the relationship of these levels to severity of acne and body mass index (BMI), in order to investigate the role of this factor in the pathogenesis of acne.</p><p class="abstract"><strong>Methods:</strong> Fifty-four patients with acne vulagaris and 42 healthy controls were included. History taking, dermatological examination, clinical assessments of acne severity, calculation of BMI were performed for patients. Blood samples were collected from all participants for estimation of serum IGF-1 level using enzyme linked immunosorbant assay.<strong></strong></p><p class="abstract"><strong>Results:</strong> There was a significantly higher serum IGF-1 level in acne patients (p&lt;0.05) than controls. Authors didn’t find a relation of significance between elevated serum IGF-1 level and degree of acne severity and BMI (p&gt;0.05). There was a significant positive correlation between serum IGF-1 level and age of the patients.</p><p class="abstract"><strong>Conclusions:</strong> There is a significantly higher serum IGF-1 in acne patients than controls not related to acne severity and BMI. That is adding to the scientific evidence of IGF-1 role in pathogenesis of acne vulgaris.</p></div>

Cutaneous warts are benign papillomas of skin caused by human papilloma virus(HPV).HPV is transmitted by direct contact with contaminated skin or indirectly via objects carrying the virus. This cross sectional study included 2060 primary school students, who were selected from 2 rural (public) and 4 urban (2 public and 2 private) primary schools in fayoum governorate. During the period from October 2017 to April 2018. The data were collected by questionnaire sheet.the prevalence of cutaneous warts was 4.7% among primary school children in Fayoum.

Premature ejaculation (PE) is defined as short ejaculatory latency and lack of control upon ejaculation. Vitamin B12 is an essential and vitally important in DNA synthesis, nervous system functions and regulation of numerous other B12-dependent metabolic processes. vitamin B12 plays integral roles in the metabolism of NO, homo cysteine and 5-HT. The aim of our study was to investigate whether a relationship exists between serum vitamin B12 levels and presence of PE. It was a cross-section, case-control study included 60 subjects divided into 2 groups. Patients group included 30 PE patients, and control group included 30 healthy matched subjects. The participants completed questionnaires concerning sexual health status including Premature Ejaculation Diagnostic Tool (PEDT) and International Index of Erectile Function (IIEF). Serum vitamin B12 was analyzed using ELISA technique. The mean IELT values in the PE group were significantly lower than in the control group (p < .0001). PE patients reported significantly lower vitamin B12 levels compared with the controls (p < .001). Patients with PE had lower vitamin B12 levels compared with normal men with a negative significant correlation between serum vitamin B12 level and PEDT score.