The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577,was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.As described in the preceding paper, tetrafibricin was a new metabolite produced by Streptomyces neyagawaensis NR0577, which potently inhibited fibrinogen binding to its receptors. In this paper, we report on the structural elucidation of tetrafibricin.Results
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