Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. VII On the antihemorrhagic principle in Cirsium japonicum DC.

Ishida, Hideyuki; Umino, Takayuki; Tsuji, Kiichiro; Kosuge, Takuo

doi:10.1248/cpb.35.861

Cited by 56 publications

(31 citation statements)

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“…Cirsium japonicum DC is a wild annual herbal plant of the Compositae family, and grows in many areas of China as well as Korea and Japan. Its leaves, roots and stalks have long been used along with other traditional Chinese medicines to treat diseases such as hypertension, traumatic hemorrhage, inflammation, and renal cellular injury (Ishida et al, 1987). The water extracts of Cirsium japonicum DC were recently reported to show estrogenic effects and vasorelaxant activity (Park et al, 2008;Kim et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats

Liao

Chen

2010

Arch. Pharm. Res.

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Cirsium japonicum DC is a traditional Chinese herb used along with other herbs to treat hypertension, traumatic hemorrhage, inflammation, and renal cellular injury. Here, we isolated two flavones from Cirsium japonicum DC, pectolinarin and 5,7-dihydroxy-6,4'-dimethoxy flavone (DDMF), and investigated their antidiabetic effect in diabetic rats established by intravenous injection with streptozotocin followed by feeding with high-carbohydrate/high-fat diet. Both pectolinarin and DDMF showed antidiabetic effect in diabetic rats. However, FECJ, a mixture of pectolinarin and DDMF, is more effective than pectolinarin and DDMF in improving the plasma glucose, cholesterol and triglycerides levels in diabetic rats. The altered activities of glucose metabolism-related enzymes in diabetic rats were well reversed after flavone treatment. The plasma adiponectin level was greatly increased in diabetic rats treated with FECJ, while no obvious effect of the flavones on the dysregulated plasma insulin level and expressions of leptin and glucose transporter 4 (GLUT4) was observed. Our data indicated that the flavones improved adiponectin expression, accompanied by restoring of the dysregulated activities of the glucose metabolism-related enzymes, ultimately resulting in well improved glucose and lipid homeostasis. Thus, an antidiabetic effect of Cirsium japonicum DC was revealed in diabetic rats, suggesting the potential benefit of the Cirsium japonicum DC as an alternative in treating diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats

Liao

Chen

2010

Arch. Pharm. Res.

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“…Paeoniflorin is a bioactive monoterpene glucoside in Paeonia radix. Paeoniflorin is known to possess an anticoagulant (Ishida et al, 1987), analgesic (Sugishita et al, 1984), anti-inflammatory and anti-allergy (Yamahara et al, 1982), and anti-oxidative activities (Kim et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Paeony plants, such as Paeonia radix, have been used for a lot of therapeutic purpose in traditional medicine. Paeonia radix possess several pharmacological effects such as analgesic (Sugishita et al, 1984), anti-inflammatory and anti-allergic (Yamahara et al, 1982), anti-oxidative (Kim et al, 1998), anti-coagulant activities (Ishida et al, 1987), and inhibitory action on steroid protein binding (Tamaya et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Aqueous extract of Paeonia radix suppresses lipopolysaccharide-induced expressions of cyclooygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells

Hong¹,

Kim²,

Yang³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYPaeonia radix is the root of Paeonia aliflora Pallas, which is a perennial plant classified in the family Paeoniaceae. Paeonia radix possesses several pharmacological effects such as analgesic, antiinflammatory and anti-allergic, anti-oxidative, and anti-coagulant activities. In this study, we investigated the effect of the aqueous extract of Paeonia radix on the lipopolysaccharide-induced inflammation in mouse BV2 microglial cells. The aqueous extract of Paeonia radix at respective concentration was treated one hour before lipopolysaccharide treatment. In the present results, the aqueous extract of Paeonia radix suppressed prostaglandin E 2 synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated mRNA expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. These results demonstrate that Paeonia radix exerts anti-inflammatory and analgesic effects probably by suppressing mRNA expressions of cyclooxygenase-2 and inducible nitric oxide synthesis. The present study demonstrates that Paeonia radix may offer a valuable mean of therapy for brain inflammatory diseases.

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“…it has been used as an anti-hemorrhagic, anti-hypertensive and uretic agent in traditional chinese medicine (6). recent studies have found that the water extracts of C. japonicum induce the activation of estrogen receptors and have estrogenic effects (7).…”

Section: Introductionmentioning

confidence: 99%

Cirsium japonicum extract induces apoptosis and anti-proliferation in the human breast cancer cell line MCF-7

Kim

Kang²,

Ghil³

2010

Mol Med Rep

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Abstract. Cirsium japonicum is a wild perennial herb that has been used as an anti-hemorrhagic, anti-hypertensive and uretic agent in traditional chinese medicine. recently, it was reported that C. japonicum inhibits the growth of implanted cancer cells. However, the molecular mechanisms underlying the anti-cancer properties of C. japonicum are not fully understood. in this study, we investigated the effect of a methanol extract of C. japonicum on cell growth in the human breast cancer cell line McF-7. C. japonicum extract inhibited the cell proliferation of McF-7 cells in a time-and dose-dependent manner, as evaluated by the MTT assay. Furthermore, C. japonicum extract induced an antiproliferative effect by causing G 1 phase cell cycle arrest and also induced apoptosis by affecting mitochondrial apoptotic events, as determined by nuclear derangement, flow cytometry and Western blot analysis. Taken together, our findings indicate that C. japonicum extract induces the inhibition of McF-7 cell growth at both the proliferation and apoptosis levels. Introductioncurrently, many efforts are underway to develop new therapeutic anti-cancer drugs from natural sources. a major natural reservoir is plant material. Plant secondary metabolites have occasionally been used as chemotherapeutic agents to mediate cytostatic activity in cancer cells. Widely used anti-mitotic anti-cancer drugs including Vinca alkaloids and paclitaxel have been isolated from Catharanthus roseus and Taxus baccata, respectively (1). The dna polymerase i inhibitor camptothecin was sourced from Camptotheca acuminata (2). curcumin isolated from Curcuma longa has shown anticancer properties, such as the inhibition of tumor promotion and the induction of apoptosis in cancer cells (3-5).Cirsium japonicum is a wild perennial herb found in many areas of Korea, Japan and china. it has been used as an anti-hemorrhagic, anti-hypertensive and uretic agent in traditional chinese medicine (6). recent studies have found that the water extracts of C. japonicum induce the activation of estrogen receptors and have estrogenic effects (7). C. japonicum also contains a vasorelaxant principle, mediating histamine H1-receptor activation (8). in traditional medicine, C. japonicum has sometimes been used for the management of different types of cancer, including liver and uterine cancer and leukemia (9).recently, it was reported that C. japonicum and its flavone components induce the inhibition of tumor formation in mice (9,10). However, the mechanism underlying the anti-cancer effects of these C. japonicum compounds are not fully understood.in the present study, we observed that a methanol extract of C. japonicum significantly reduced cancer cell growth in a time-and dose-dependent manner, using the human breast cancer cell line McF-7. Furthermore, we investigated the molecular mechanisms underlying the anti-proliferative activities of C. japonicum. Materials and methodsPreparation of C. japonicum extract. dried roots of C. japonicum from Korea were purchased from the Kyungd...

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Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. VII On the antihemorrhagic principle in Cirsium japonicum DC.

Cited by 56 publications

References 0 publications

Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats

Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats

Aqueous extract of Paeonia radix suppresses lipopolysaccharide-induced expressions of cyclooygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells

Cirsium japonicum extract induces apoptosis and anti-proliferation in the human breast cancer cell line MCF-7

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