Right ventricular (RV) dysfunction, caused by severe pulmonary hypertension (PH), is associated with high mortality because of RV failure. However, some patients can suffer from sudden cardiac death (SCD). We hypothesized that severe PH can cause RV arrhythmogenesis, leading to SCD. We sought to investigate arrhythmogenesis in PH. Optical mapping analysis (OMP) with an electrophysiological study (EPS) and pathological examination were performed in a monocrotaline (MCT)-induced rat PH model. Rats were injected with MCT (60 mg/kg), and OMP was performed in isolated Langendorff-perfused hearts. OMP revealed abnormal RV conduction delays and abnormal patterns, along with elevated RV pressure. In addition, impaired action potential duration dispersion (APDd), an index of myocardial repolarization instability, was observed only in the RVs with severe PH. The EPS demonstrated that lethal arrhythmias were induced by burst pacing to the RV when deteriorated APDd became evident. This arrhythmogenesis was inhibited by combination treatment with sildenafil and beraprost (SIL + BERA). RT-PCR showed an mRNA up-regulation of Type I collagen and down-regulation of connexin-43 in the RV at 5 weeks after MCT injection. Pathological examination revealed pulmonary vascular remodeling and RV hypertrophy with interstitial fibrosis, which was substantially reduced by SIL + BERA. Immunohistochemistry also revealed connexin-43 degradation in the RVs with severe PH. In contrast, connexin-43 was well preserved, and no lethal arrhythmias were induced by burst pacing to the RV in the absence of PH after SIL + BERA. In conclusion, RV electrical remodeling, including impaired APDd, causes arrhythmogenesis in severe PH, potentially associated with SCD attributable to PH.

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A 74−year−old Japanese man newly pres− ented with gastric polyposis, 2 years after intermittent administration of lornoxi− cam 12 mg (a new potent nonsteroidal anti−inflammatory drug) and nizatidine 300 mg daily (a histamine 2 −receptor an− tagonist) for knee joint pain and abdomi− nal discomfort, respectively. Gastroscopy (Figure 1 a, b) and double−contrast radio− graphy (Figure 1 c) showed multiple small hemispheric polyps circularly oriented in the gastric antrum, with tubular narrow− ing. On histology, the polyps were found to consist of inflamed granulation tissue, with immature regenerative epithelium (Figure 1 d).Nonsteroidal anti−inflammatory drugs (NSAIDs) are a well−known cause of acute gastric mucosal lesions, characterized by multiple shallow ulcers in the gastric an− trum. In the hypoacidic conditions in− duced by a histamine 2 −receptor antago− nist, inflammatory polyps may arise in a rapid and excessive regenerative process after gastric mucosal injury due to NSAID administration.

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