A Case of Cronkhite-Canada Syndrome With Colorectal Adenomas: Effect of the Nonsteroidal Anti-Inflammatory Drug Sulindac

Hizawa, Kazuoki; Nakamori, Mari; Yao, Takashi; Matsumoto, Takayuki; Iida, Mitsuo

doi:10.1111/j.1572-0241.2007.01237.x

Cited by 6 publications

(2 citation statements)

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“…Usually, available management includes nutritional support, administration of zinc, acid suppression, cromolyn sodium, corticosteroid, and eradication of H. pylori . In one case, the successful use of nonsteroidal anti-inflammatory drugs to regress CCS polyps was described,4 but many anecdotal reports support the use of corticosteroid 20. However, the number of data supporting corticosteroid use are insufficient, so it is difficult to accept that as a recommendation.…”

Section: Discussionmentioning

confidence: 99%

Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and a Literature Review of 13 Cronkhite-Canada Syndrome Cases in Korea

et al. 2013

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Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances both in the gastrointestinal tract and in the epidermis. The pathologic finding of the polyp is usually a hamartomatous polyp of the juvenile type; however, the possibility of serrated adenoma associated malignant neoplasm was reported in some Japanese cases. Up till now in South Korea, 13 CCS cases have been reported, but there was no case accompanied by the colon cancer. We report the first case of CCS associated with malignant colon polyp and serrated adenoma in Korea. A 72-year-old male patient who complained of diarrhea and weight loss was presented with both hands and feet nail dystrophy, hyperpigmentation, and alopecia. Endoscopic examination showed numerous hamartomatous polyps from the stomach to the colon. The pathologic results confirmed colon cancer and serrated adenoma. Helicobacter pylori eradication and prednisolone was used. Thus, the authors report this case along with a literature review.

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Section: Discussionmentioning

confidence: 99%

Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and a Literature Review of 13 Cronkhite-Canada Syndrome Cases in Korea

et al. 2013

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“…Nails show dystrophic changes and, in advanced cases, easily detached themselves from nail bed. CCS is included in the differential diagnosis of the gastrointestinal polyposis, non adenomatous and non inherited, as lym- phoid nodular hyperplasia and hyperplasic, inflammatory, lipomatous or lymphomatous polyposis (1)(2)(3)8,(12)(13)(14)(15)(16). It is a very infrequent disease, at least in occidental countries, leading most of published cases to Asiatic countries.…”

Section: Discussionmentioning

confidence: 99%

Cronkhite-Canada syndrome: a new case report of this enigmatic and infrequent disease

Maraver-Zamora

Pinto-Morales

Sánchez

et al. 2010

Rev. esp. enferm. dig.

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Kolorektale Polyposen

2011

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Biopsies and resection specimens of the gastrointestinal tract are a major part of the routine workload in many histopathology departments, whereby polypoid lesions are generally the main focus. In addition to distinguishing non-neoplastic from neoplastic polyps and evaluating the grade of dysplasia of the latter, the pathologist should always consider the possibility of an underlying polyposis syndrome. Not only have additional hereditary polyposis syndromes been identified in recent years due to a better understanding of their genetic and epigenetic alterations but also knowledge on well known polyposes has improved, leading to subtyping of various forms according to their different genotype. It is essential for the histopathologist to understand that the conventional histomorphology of individual polyps combined with information on the number and distribution of these lesions and clinical data can provide clues regarding a possible hereditary background. Therefore, the correct histological assessment of polyps is not just about getting the diagnosis right, it might also lead to genetic screening of family members and spouses.

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A Case of Cronkhite-Canada Syndrome With Colorectal Adenomas: Effect of the Nonsteroidal Anti-Inflammatory Drug Sulindac

Cited by 6 publications

References 3 publications

Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and a Literature Review of 13 Cronkhite-Canada Syndrome Cases in Korea

Cronkhite-Canada Syndrome Associated with Serrated Adenoma and Malignant Polyp: A Case Report and a Literature Review of 13 Cronkhite-Canada Syndrome Cases in Korea

Cronkhite-Canada syndrome: a new case report of this enigmatic and infrequent disease

Kolorektale Polyposen

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