Background-While a close association between gastric mucosa associated lymphoid tissue (MALT) lymphoma andHelicobacter pylori infection has been established, there are still cases which do not respond to H pylori eradication. Aims-To investigate the clinicopathological factors which may help predict the therapeutic eYcacy of H pylori eradication in gastric MALT lymphoma. Patients-Forty one patients with gastric MALT lymphoma, including low and high grade lesions. Methods-After endosonographic staging was determined, H pylori was eradicated in all patients, and the subsequent gastric pathological course was then investigated. Results-Complete regression of MALT lymphoma was observed in 29(71%) patients, partial regression in five (12%), and no regression in seven (17%). Twenty six (93%) of 28 MALT lymphomas restricted to the mucosa but only three (23%) of 13 lymphomas which invaded the deep portion of the submucosa or beyond completely regressed. Kaplan-Meier analysis for the probability of complete regression of MALT lymphoma revealed a significant diVerence between tumours restricted to the mucosa and those invading the submucosa deeply or beyond (p<0.05). Neither the presence of a high grade component, perigastric lymphadenopathy, nor clinical staging prior to eradication correlated with the probability of lymphoma regression. Conclusions-Assessment of deep submucosal invasion by endosonography is valuable for predicting the eYcacy of H pylori eradication in gastric MALT lymphoma. (Gut 2001;48:454-460)

Endoscopic resection is indicated in intramucosal gastric cancer lesions showing differentiated histology, no ulcer fibrosis and a diameter of less than 2 cm. EUS may additionally be used for further evaluation in these patients.

EN is a prophylactic that prevents the postoperative recurrence of small intestinal CD. Patients with the penetrating type of CD, and those who do not have active lesions in the small intestine according to IOE, are candidates for EN after surgery.

Neoplastic transformation is not a rare event, and our results may indicate evidence of a hamartoma-adenoma-carcinoma sequence in Peutz-Jeghers polyposis.

Aims-To clarify a clinical entity of juvenile polyposis of the stomach compared with generalised juvenile gastrointestinal polyposis. Methods-The clinicopathological features of juvenile polyposis dominantly involving the stomach at initial presentation were reviewed in 12 patients (three new patients and nine from the literature). These were compared with 29 cases of generalised juvenile gastrointestinal polyposis.

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Endosonography is a useful diagnostic modality for investigating cystic submucosal tumors.