Peri-implant squamous cell carcinoma is an uncommon pathological manifestation, whereas peri-implantitis is commonly found in association with dental implants. Both present similarly with loss of supporting soft and hard tissue around dental implants; therefore, a careful differential diagnosis is required. The present case concerns a 62-year-old Japanese man who had a dental implant which had been in the left maxillary incisor region for 4 years who apparently developed peri-implantitis. This did not respond to localized therapy and antibiotics so was referred for specialist surgical management. A biopsy confirmed it to be a squamous cell carcinoma rather than an inflammatory lesion. A literature review shows that this is an unusual presentation without a previous history of malignancy, mucosal disease or risk factors for cancers. Although rare, the possibility of peri-implant squamous cell carcinoma should be borne in mind by all practitioners who monitor implant patients.
Abstruct: Plasma rich in growth factors (PRGF) had been used in regenerative therapy such as soft tissue and newly bone formation. However, there has been little basic research into the efficacy of PRGF in bone regeneration. In this study, we evaluated the efficacy for new bone formation by transplantation of PRGF onto rat calvaria. The osteogenic potential was evaluated by histologic findings, immunohistochemistry and bone formation analyzed with micro-computed tomography (micro-CT). PRGF was prepared by centrifugation of rat whole blood (WB), and then was activated using 10% calcium chloride solution. The activated PRGF transplanted within a polytetrafluoroethylene (PTFE) tube was transplanted onto calvarial bone of rats. Histological observation demonstrated that PRGF group showed newly formed bone in a wide range. Immunohistochemistry showed Runx2, Osterix, Bone Alkaline Phosphatase (BAP) and Osteocalcin expressed in PRGF group during the early stage of bone formation. Micro-CT showed that PRGF group promoted an increase in bone volume which compared to control group. We concluded that PRGF has more capacity for bone regeneration, and PRGF may be useful in bone regeneration treatment.
The purpose of this study was to examine the histopathological and immunohistochemical characteristics of the dental follicle (DF) attached to impacted tooth. A total of 38 cases of DF diagnosed histopathologically between 2000 and 2011 at the Department of Oral Pathology, Nihon University School of Dentistry, Matsudo City, Japan were used in the study. Among the 38 cases, 10 cases which did not undergo decalcification were selected for immunohistochemistry. Histologically, the DF was composed of inner and outer layers. In the inner layer, myxoid tissue, dilated capillaries and peripheral nerve were observed in 100%, 83.3% and 26.3% of the cases respectively. Vessel density in the inner layer is 11 times more than in the outer layer. Capillary dilatation in the inner layer was observed in 83.3% with 107.8 ±124.0µm 2 but was not observed in the outer layer with 3.4±2.4 µm 2 in average, either. Lymph vessel density in the inner layer is more frequent than in the outer layer. Odontogenic epithelial islands and calcification were more prominent in the inner layer (55.3%, 31.6%) compared to those in the outer layer (2.9%, 2.6%). The mesenchymal cells in the inner layer were positive to Vimentin and α-SMA but only weakly positive to FGF-2 and VEGF. Cells positive to CD68 were scattered and cells focally positive to Runx2 were observed near the region of inflammatory cell infiltration. The odontogenic epithelial islands were positive to FGF-2 and p63. The results suggest that the ectomesenchymal cells in the inner layer of the DF are concerned with abundant vascular formation. Further, inflammatory irritation to the inner layer might have caused osteoblastic differentiation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.