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This study is the first to investigate whether ALI is useful for predicting postoperative survival in patients with NSCLC. Preoperative ALI might serve as a potentially clinically valuable marker of the prognosis for patients with operable NSCLC.

Relationship between thrombocytosis and poor prognosis has been reported in lung cancer. However, the majority of previous studies included many advanced stage and small cell lung cancer patients. Few studies focused on resectable non-small cell lung cancer patients. In the present study, therefore, consecutive 240 non-small cell lung cancer patients who received surgical resection were reviewed retrospectively, and investigated the survival impact of preoperative platelet count. In our results, the frequency of preoperative thrombocytosis was only 5.83% (14/240). The 5-year survival of patients with and without thrombocytosis was 28.87% and 63.73%, respectively. Both univariate and multivariate analyses indicated the independent prognostic impact of thrombocytosis. The present study is the first evaluation of prognostic effect of thrombocytosis in patients with resectable non-small cell lung cancer. Preoperative platelet count was a prognostic factor for resectable non-small cell lung cancer patients.

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Background: The previous study of ours showed the prognostic impact of preoperative neutrophil to lymphocyte ratio (NLR) in resected non-small cell lung cancer (NSCLC) patients. Methods: In the present study, the relationship between postoperative NLR and patients' prognosis was examined in NSCLC patients with preoperative high NLR. Consecutive 85 resected NSCLC patients with preoperative high NLR (≥2.5) were reviewed retrospectively. In this study, patients with a follow-up period less than 5 years were omitted. Results: Among these 85 patients, the postoperative NLR in 46 patients were persistently higher than 2.5. The 5-year survival of the patients with postoperative NLR≥2.5 was significantly worse than that of the patients with postoperative NLR<2.5 (34.78% vs. 61.54%, p=0.0067). Univariate and multivariate analyses of the clinicopathological factors affecting survival revealed that postoperative high NLR was an independent prognostic determinant. Conclusion: NSCLC patients with preoperative high NLR, patients with a persistently high NLR after surgery had poor prognosis.