The prevalence of food allergies is increasing globally. 1 Although strict avoidance is mandatory for severe food allergies, accidental ingestion frequently occurs. 2 The frequency of accidental ingestion depends on an individual's threshold for food allergens. 3 An individual's threshold provides information on the maximum tolerable doses and minimum eliciting doses. 4 Although studies have revealed threshold doses for different allergens, 4-8 evidence regarding risk factors for a low threshold dose is limited.Increased specific immunoglobulin E (sIgE) levels are associated with anaphylaxis 9 and severe reactions 10 during oral food challenges (OFCs). Peanut and Ara h 2 sIgE levels have been reported as risk factors for a low threshold dose in the peanut OFC. 11,12 Nevertheless,

Food allergy is a disease with diversity and variable natural history.Most patients acquire tolerance as they mature, whereas some patients have persistent symptoms. For example, 70%-80% of patients with allergy to hen's egg naturally acquire tolerance by the age of 6 years. 1 In addition, some patients may have food allergy to two or more antigens concomitantly. Among atopic disease patients, 57% reacted to two or three foods in oral food challenges (OFCs). 2 Patients can develop symptoms from accidental ingestion, 3 and their

No abstract