Long-term follow-up of fixed low-dose oral immunotherapy for children with wheat-induced anaphylaxis

Nagakura, Ken‐ichi; Miura, Yoko; Itonaga, Takaaki; Nishino, Makoto; Takahashi, Kyohei; Ogura, Kiyotake; Sato, Sakura; Yanagida, Noriyuki; Ebisawa, Motohiro

doi:10.1016/j.jaip.2021.12.013

Cited by 18 publications

(15 citation statements)

References 8 publications

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“…Table 1 summarizes the published clinical trials for wheat OIT protocols demonstrating wide variability, with efficacy being defined differently between trials [21][22][23]50,[75][76][77][78][79][80][81][82][83]. For example, the types of wheat products utilized for the immunotherapy varied among studies -some used pasta, others used udon and bread, to name a few.…”

Section: Clinical Trialsmentioning

confidence: 99%

Novel Diagnostic and Immunotherapeutic Approaches for Wheat Allergy

Zheng,

Wai,

Sit

et al. 2024

Preprint

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Wheat, a component of the staple diet globally, is a common food allergen in children. The symptoms of wheat allergy (WA) range from skin rash to shortness of breath, significantly impairing quality of life. Following initial clinical suspicion, individuals may undergo wheat allergen-specific skin prick test (SPT), blood test for serum immunoglobulin E (sIgE) levels or oral food challenge. Conventional management of WA lies in wheat avoidance, yet accidental consumption may be inevitable owing to the ubiquity of wheat in various food products. This article aims to provide an overview of the immunologic pathway of WA, followed by its novel diagnostic methods, namely alcohol-soluble SPT extracts, component-resolved diagnosis and basophil activation test (BAT). The mechanisms underlying wheat allergen-specific oral immunotherapy (OIT) as well as a summary of the efficacy, tolerability and safety of related clinical trials will then be discussed.

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Section: Clinical Trialsmentioning

confidence: 99%

Novel Diagnostic and Immunotherapeutic Approaches for Wheat Allergy

Zheng,

Wai,

Sit

et al. 2024

Preprint

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“…Recently, in an oral immunotherapy trial, ingesting low-dose peanuts (133-300 mg) could induce immunological changes and allow the intake of larger amounts. 8,9 Similarly, twice weekly ingestion of 133 mg in the low-dose-tolerant group may yield oral tolerance.…”

Section: F I G U R E 2 (A)mentioning

confidence: 99%

Long‐term prognosis after low‐dose peanut challenge for patients with a history of anaphylaxis

Akamatsu,

Nagakura,

Sato

et al. 2023

Pediatric Allergy Immunology

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“…Although strict avoidance is mandatory for severe food allergies, accidental ingestion frequently occurs 2 . The frequency of accidental ingestion depends on an individual's threshold for food allergens 3 . An individual's threshold provides information on the maximum tolerable doses and minimum eliciting doses 4 .…”

Section: Introductionmentioning

confidence: 99%

“…2 The frequency of accidental ingestion depends on an individual's threshold for food allergens. 3 An individual's threshold provides information on the maximum tolerable doses and minimum eliciting doses. 4 Although studies have revealed threshold doses for different allergens, 4-8 evidence regarding risk factors for a low threshold dose is limited.Increased specific immunoglobulin E (sIgE) levels are associated with anaphylaxis 9 and severe reactions 10 during oral food challenges (OFCs).…”

mentioning

confidence: 99%

Relationship between serum allergen‐specific immunoglobulin E and threshold dose in an oral food challenge

Yanagida

Sato

Nagakura

et al. 2023

Pediatric Allergy Immunology

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The prevalence of food allergies is increasing globally. 1 Although strict avoidance is mandatory for severe food allergies, accidental ingestion frequently occurs. 2 The frequency of accidental ingestion depends on an individual's threshold for food allergens. 3 An individual's threshold provides information on the maximum tolerable doses and minimum eliciting doses. 4 Although studies have revealed threshold doses for different allergens, 4-8 evidence regarding risk factors for a low threshold dose is limited.Increased specific immunoglobulin E (sIgE) levels are associated with anaphylaxis 9 and severe reactions 10 during oral food challenges (OFCs). Peanut and Ara h 2 sIgE levels have been reported as risk factors for a low threshold dose in the peanut OFC. 11,12 Nevertheless,

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Long-term follow-up of fixed low-dose oral immunotherapy for children with wheat-induced anaphylaxis

Cited by 18 publications

References 8 publications

Novel Diagnostic and Immunotherapeutic Approaches for Wheat Allergy

Novel Diagnostic and Immunotherapeutic Approaches for Wheat Allergy

Long‐term prognosis after low‐dose peanut challenge for patients with a history of anaphylaxis

Relationship between serum allergen‐specific immunoglobulin E and threshold dose in an oral food challenge

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