In this study, general methods were applied for the preparation of new iminopyridazine butyronitriles. A series of six new 4-(3-aryl-1,6-dihydro-6-iminopyridazin-1-yl)butyronitrile hydro-bromides (2a-2f) (Scheme 1) have been prepared starting from commercially available 3-amino-6-chloropyridazine in two steps with good yields. The synthesized compound’s structures were characterized by IR, 1H NMR and high-resolution mass structures spectral (HRMS) data. Journal of Bangladesh Academy of Sciences, Vol. 44, No. 2, 131-138, 2020

A series of six title compounds have been prepared using 3-amino- 6-chloropyridazine as starting material collected from commercial sources and were characterized by IR, 1H NMR, and high-resolution mass spectral (HRMS) data. The method involves three steps: Suzuki-Miyaura cross-coupling reaction, N(2)-alkylation, and acid hydrolysis, respectively, to obtain final products with good yields. According to Lipinski's rule of five and Veber's rule, pharmacokinetics studies of the synthesized compounds showed that all the parameters were in between the permissible limits. The toxicity parameters were low for the compounds to act as drugs. J. Bangladesh Acad. Sci. 45(1); 37-47: June 2021

Phytochemical screening and gas chromatography-mass spectrometry (GC-MS) methods were used to determine the phytochemical components of various extracts of stems and roots of Catharanthus roseus. Preliminary phytochemical screening of n-hexane, chloroform, ethyl acetate and methanol extracts of stems and roots of Catharanthus roseus were carried out to identify the class of compounds present in each extract. The results exhibited that steroids, terpenoids, flavonoids and phenolic compounds were found in every extract of stems and roots. Alkaloids were also found in all extracts except n-hexane. But carbohydrates were absent in all extracts of stems and roots except methanol. The GC-MS analysis of the n-hexane extract of the stems and roots of Catharanthus roseus was done, which allowed the identification and quantification of 30 and 22 n-hexane soluble compounds present in the stems and roots, respectively. In this experiments, D:B-Friedo-B':A'-neogammacer-5-en-3β-ol (10.23%) and Ethyl palmitate (13.63%) identified with the highest concentration in the n-hexane extract of stems and roots, respectively.

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