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In this article, we present the transmission dynamic of the acute and chronic hepatitis B epidemic problem and develop an optimal control strategy to control the spread of hepatitis B in a community. In order to do this, first we present the model formulation and find the basic reproduction number R 0 . We show that if R 0 ≤ 1, then the disease-free equilibrium is both locally as well as globally asymptotically stable. Then, we prove that the model is locally and globally asymptotically stable, if R 0 > 1. To control the spread of this infection, we develop a control strategy by applying three control variables such as isolation of infected and non-infected individuals, treatment and vaccination to minimize the number of acute infected, chronically infected with hepatitis B individuals and maximize the number of susceptible and recovered individuals. Finally, we present numerical simulation to illustrate the feasibility of the control strategy. ARTICLE HISTORY

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Number of well-known contagious diseases exist around the world that mainly include HIV, Hepatitis B, influenzas etc., among these, a recently contested coronavirus (COVID-19) is a serious class of such transmissible syndromes. Abundant scientific evidence the wild animals are believed to be the primary hosts of the virus. Majority of such cases are considered to be human-to-human transmission, while a few are due to wild animals-to-human transmission and substantial burdens on healthcare system following this spread. To understand the dynamical behavior such diseases, we fitted a susceptible-infectious-quarantined model for human cases with constant proportions. We proposed a model that provide better constraints on understanding the climaxes of such unseen disastrous spread, relevant consequences, and suggesting future imperative strategies need to be adopted. The main features of the work include the positivity, boundedness, existence and uniqueness of solution of the model. The conditions were derived under which the COVID-19 may extinct or persist in the population. Sensitivity and estimation of those important parameters have been carried out that plays key role in the transmission mechanism. To optimize the spread of such disease, we present a control problem for further analysis using two control measures. The necessary conditions have been derived using the Pontryagin’s maximum principle. Parameter values have been estimated from the real data and experimental numerical simulations are presented for comparison as well as verification of theoretical results. The obtained numerical results also present the verification, accuracy, validation, and robustness of the proposed scheme.

This paper is related to the existence and uniqueness of solutions to a coupled system of fractional differential equations (FDEs) with nonlinear -Laplacian operator by using fractional integral boundary conditions with nonlinear term and also to checking the Hyers-Ulam stability for the proposed problem. The functions involved in the proposed coupled system are continuous and satisfy certain growth conditions. By using topological degree theory some conditions are established which ensure the existence and uniqueness of solution to the proposed problem. Further, certain conditions are developed corresponding to Hyers-Ulam type stability for the positive solution of the considered coupled system of FDEs. Also, from applications point of view, we give an example.

The proposed investigation concerns the impact of inclined magnetohydrodynamics (MHD) in a Casson axisymmetric Marangoni forced convective flow of nanofluids. Axisymmetric Marangoni convective flow has been driven by concentration and temperature gradients due to an infinite disk. Brownian motion appears due to concentration of the nanosize metallic particles in a typical base fluid. Thermophoretic attribute and heat source are considered. The analysis of flow pattern is perceived in the presence of certain distinct fluid parameters. Using appropriate transformations, the system of Partial Differential Equations (PDEs) is reduced into non-linear Ordinary Differential Equations (ODEs). Numerical solution of this problem is achieved invoking Runge–Kutta fourth-order algorithm. To observe the effect of inclined MHD in axisymmetric Marangoni convective flow, some suitable boundary conditions are incorporated. To figure out the impact of heat/mass phenomena on flow behavior, different physical and flow parameters are addressed for velocity, concentration and temperature profiles with the aid of tables and graphs. The results indicate that Casson fluid parameter and angle of inclination of MHD are reducing factors for fluid movement; however, stronger Marangoni effect is sufficient to improve the velocity profile.