Airborne respiratory diseases such as COVID-19 pose significant challenges to public transportation. Several recent outbreaks of SARS-CoV-2 indicate the high risk of transmission among passengers on public buses if special precautions are not taken. This study presents a combined experimental and numerical analysis to identify transmission mechanisms on an urban bus and assess strategies to reduce risk. The effects of the ventilation and air-conditioning systems, opening windows and doors, and wearing masks are analyzed. Specific attention is paid to the transport of submicron- and micron-sized particles relevant to typical respiratory droplets. High-resolution instrumentation was used to measure size distribution and aerosol response time on a campus bus of the University of Michigan under these different conditions. Computational fluid dynamics was employed to measure the airflow within the bus and evaluate risk. A risk metric was adopted based on the number of particles exposed to susceptible passengers. The flow that carries these aerosols is predominantly controlled by the ventilation system, which acts to uniformly distribute the aerosol concentration throughout the bus while simultaneously diluting it with fresh air. The opening of doors and windows was found to reduce the concentration by approximately one half, albeit its benefit does not uniformly impact all passengers on the bus due to the recirculation of airflow caused by entrainment through windows. Finally, it was found that well fitted surgical masks, when worn by both infected and susceptible passengers, can nearly eliminate the transmission of the disease.

Background Natural products have increasingly attracted much attention as a valuable resource for the development of anticancer medicines due to the structural novelty and good bioavailability. This necessitates a comprehensive database for the natural products and the fractional extracts whose anticancer activities have been verified.DescriptionNPCARE (http://silver.sejong.ac.kr/npcare) is a publicly accessible online database of natural products and fractional extracts for cancer regulation. At NPCARE, one can explore 6578 natural compounds and 2566 fractional extracts isolated from 1952 distinct biological species including plants, marine organisms, fungi, and bacteria whose anticancer activities were validated with 1107 cell lines for 34 cancer types. Each entry in NPCARE is annotated with the cancer type, genus and species names of the biological resource, the cell line used for demonstrating the anticancer activity, PubChem ID, and a wealth of information about the target gene or protein. Besides the augmentation of plant entries up to 743 genus and 197 families, NPCARE is further enriched with the natural products and the fractional extracts of diverse non-traditional biological resources.ConclusionsNPCARE is anticipated to serve as a dominant gateway for the discovery of new anticancer medicines due to the inclusion of a large number of the fractional extracts as well as the natural compounds isolated from a variety of biological resources.Electronic supplementary materialThe online version of this article (doi:10.1186/s13321-016-0188-5) contains supplementary material, which is available to authorized users.

The effects of a broad range of fuel injection strategies on thermal efficiency and engine-out emissions (CO, total hydrocarbons, NOx and particulate number) were studied for gasoline and ethanol fuel blends. A state-of-the-art production multi-cylinder turbocharged gasoline direct injection engine equipped with piezoelectric injectors was used to study fuels and fueling strategies not previously considered in the literature. A large parametric space was considered including up to four fuel injection events with variable injection timing and variable fuel mass in each injection event. Fuel blends of E30 (30% by volume ethanol) and E85 (85% by volume ethanol) were compared with baseline E0 (reference grade gasoline). The engine was operated over a range of loads with intake manifold absolute pressure from 800 to 1200 mbar. A combined application of ethanol blends with a multiple injection strategy yielded considerable improvement in engine-out particulate and gaseous emissions while maintaining or slightly improving engine brake thermal efficiency. The weighted injection spread parameter defined in this study, combined with the weighted center of injection timing defined in the previous literature, was found well suited to characterize multiple injection strategies, including the effects of the number of injections, fuel mass in each injection and the dwell time between injections.

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