Objective: The aim of the present study was to analyze potential drug interactions and adverse reactions to NSAIDs in elderly users of a private drug distribution service. Method: A prospective, exploratory and descriptive study with a quantitative approach was performed. The elderly users of NSAIDs attended by the service were interviewed and their prescriptions analyzed between May and September, 2014. Analysis of drug interactions was performed through computerized databases. The post-sales analysis of adverse reactions was performed using the Adverse Drug Reaction Probability Scale. Statistical analysis was performed with the Chi-squared and Fisher's Exact tests. Results: The study evaluated 200 elderly persons, among whom women predominated (56.5%). The average age was 65 years ±10. The NSAIDs accounted for 38.7% of prescription drugs used, and included dipyrone (26.9%), nimesulide (22.8%) and ketoprofen (16.3%). A total of 8.5% of such drugs were considered inappropriate medications for the elderly. A total of 104 potential drug interactions were identified, of which 24% were considered highly clinically significant. The NSAIDs with the greatest risk of interactions were ketoprofen 46.2%, ketorolac 14.4%, nimesulide 12.5% and diclofenac 9.6%. In post-sales monitoring 30.5% of the elderly persons reported undesirable symptoms after the use of NSAIDs, with stomach discomfort the most prevalent (17%). Conclusion: The present study confirmed the importance of monitoring the use of NSAIDs among the elderly due to the increased risk of drug interactions and adverse reactions associated with age, concomitant diseases, multi-prescriptions and polypharmacy. The choice of appropriate drugs for the elderly, the reconciliation of all the medications taken by the patient, and effective pharmaceutical care are measures that can contribute to the rational and safe use of NSAIDs.

Os hospitais veterinários possuem características que os distinguem de hospitais humanos. No entanto, os princípios básicos de assepsia, desinfecção, esterilização e uso de antimicrobianos são semelhantes. O objetivo deste trabalho foi implementar uma Comissão de Controle de Infecção Hospitalar (CCIH), visando monitorar e diminuir os índices de Infecções Hospitalares (IH) e o desenvolvimento de cepas resistentes. A implementação da CCIH, bem como seus Procedimentos Operacionais Padrão (POP’s) ocorreram no período entre 02 de março a 30 de setembro de 2009, no Hospital Veterinário ‘Dr. Halim Atique’, em São José do Rio Preto – SP. As principais medidas executadas foram a utilização do álcool 70% na forma farmacêutica de gel e programa de treinamento de higienização correta das mãos. Adequação do uso do digluconato de clorexidina 2% para assepsia cirúrgica em substituição a polivinilpirrolidona-iodo 10%, por seu maior efeito residual. Outra medida foi à troca do glutaraldeído 2% por ácido peracético 35% para desinfecção e esterilização química de materiais, além da utilização e monitoramento dos métodos de esterilização em autoclaves por meio de controles químico e microbiológico. Apesar de não haver legislação vigente para as CCIHs em hospitais veterinários, essas medidas são ferramentas imprescindíveis para a redução das infecções, devendo ser executadas adequadamente e monitoradas.

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