The teratogenicity of vitamin A has been repeatedly reported in the literature and confirmed on the basis of several cases of adverse pregnancy outcome associated with maternal isotretinoin exposure. We report a case which shows a striking similarity with this syndrome, but the child was born to a mother who took a normal supplementation of vitamin A during pregnancy. The differential diagnosis is discussed.
Recent observations (1-6) have focused attention on a relationship of the anterior pituitary, the thymus, and the thymusdependent lymphoid system. It has been proposed that growth hormone mediates pituitary control of the thymus (2), but the possibility of a more specific thymotropic hormone has not been excluded.In order to gain more insight into the pituitary control of immunologic function, we have studied immunologic recovery after sublethal irradiation of young adult hypophysectomized rats. The results indicated that hypophysectomy interfered with immunologic recovery after total body irradiation.Materials and Methods. Male Wistar-Furth rats (A. R. Schmidt Co., Madison, Wisconsin), hypophysectomized at 8 weeks of age, were exposed to 500 R of total body irradiation at 10 weeks of age. Normal, irradiated, and hypophysectomized nonirradiated rats were included as controls. Because hypophysectomized rats do not tolerate low ambient temperatures, all rats were maintained at 84 t 2°F. They were fed Purina Rat Chow and given tap water ad libitum.Each rat was bled from the tail at 24 hr and again at 7 weeks after irradiation, and the peripheral white blood cell count was determined.
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