Induction of Immunological Tolerance to Male Skin Isografts in Female Mice Subsequent to Neonatal Period.

Mariani, T; Martínez, Carlos A.; Smith, Julius; Good, Robert A.

doi:10.3181/00379727-101-25030

Cited by 43 publications

(8 citation statements)

References 2 publications

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“…l l u s , it seems apparent that the chick embryo is capable of a response to endotoxin, similar tol that described in mature animals ( 2, 3) , which results in an enhanced non-specific resistance to bacterial infection. Resistance could also be stimulated by inoculation of killed E .…”

supporting

confidence: 69%

“…Female mice of this strain regularly reject skin grafts taken from isologous males although the antigenic disparity between donor and recipient is rather weak allowing induction of tol- erance in the females to male skin graft by exposure to the male antigen during the neonatal period as well as during adult life (3,4). Female mice of this strain regularly reject skin grafts taken from isologous males although the antigenic disparity between donor and recipient is rather weak allowing induction of tol- erance in the females to male skin graft by exposure to the male antigen during the neonatal period as well as during adult life (3,4).…”

mentioning

confidence: 99%

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Male Skin Isograft Survival in Pregnant and Multiparous Female Mice.

Vener

Martínez

Good

1961

Experimental Biology and Medicine

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Breyere and Barrett have demonstrated that multiparous female mice of the BALB cAn strain which had borne litters of strain DBA/2 males became tolerant of a transplanted sarcoma originated in DBA/2 strain mice ( 1 ) . Recently Prehn ( 2 ) demonstrated that female mice of the C57Bl/An strain parous by repeated matings to littermate males accepted male skin isografts in high proportion of cases. Furthermore, the incidence of tolerance of male graft was proportional to the number of litters borne by the female recipient. Thus, while 60% of the females having 1-3 litters were tolerant of male skin isografts, 90% of those having 4-6 litters were also tolerant and accepted male skin isograf ts.In the experiments reported herein studies were undertaken to determine male skin isograft survival in multiparous female mice of the C57B1 (Subline l ) o strain. Female mice of this strain regularly reject skin grafts taken from isologous males although the antigenic disparity between donor and recipient is rather weak allowing induction of tol-

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supporting

confidence: 69%

mentioning

confidence: 99%

Male Skin Isograft Survival in Pregnant and Multiparous Female Mice.

Vener

Martínez

Good

1961

Experimental Biology and Medicine

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“…However, this assumption was not supported by some of the earliest therapeutically relevant experiments showing that neither "space" nor even immunosuppression was required in adult mice for production of chimerism and tolerance under specific circumstances that were largely determined by histocompatibility variables. In 1959, Mariani, Martinez, Smith, and Good (46) reported that adult splenocytes could induce chimerism and tolerance to skin grafts across the sex-linked Eichwald-Silmser histocompatibility difference in immunologically competent mature unconditioned syngeneic mice. Brent and Gowland (47) described the same thing in selected allogeneic mouse strain combinations, using frequent inoculations of very large numbers of cells.…”

Section: Discussionmentioning

confidence: 99%

Variable Chimerism, Graft-Versus-Host Disease, and Tolerance After Different Kinds of Cell and Whole Organ Transplantation From Lewis to Brown Norway Rats

MURASE¹,

Starzl²,

TANABE³

et al. 1995

Transplantation

132

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The bidirectional paradigm of tolerance involving reciprocal host vs. graft and graft vs. host reactions was examined after Lewis (LEW) → Brown Norway (BN) transplantation of different whole organs (liver, intestine, heart, and kidney) or of 2.5×10 8 LEW leukocytes obtained from bone marrow, spleen, lymph nodes, and thymus. The experiments were performed without immunosuppression or under 14 daily doses of postoperative tacrolimus, which were continued in weekly doses to 100 days in a "continuous treatment" subgroup, and to 27 days in a short treatment group. Without immunosuppression, all organs and cell suspensions failed to engraft or were acutely rejected. GVHD (usually fatal) was always caused when either the long or short treatment was used for recipients of intestinal grafts and cell suspensions of spleen and lymph nodes. In contrast, both immunosuppressive protocols allowed engraftment of bone marrow cells, liver, heart, and kidney without clinical GVHD, whereas thymus cell suspensions and small doses of whole blood neither engrafted nor caused GVHD. At 100 days, now drug-free for 73 days, the liver, bone marrow, and heart recipients were tolerant in that they accepted all challenge LEW heart and/or liver grafts for 100 more days despite in vitro evidence of donor-specific reactivity (split tolerance). At 200 days, histopathologic studies of the challenge livers were normal no matter what the priming graft. However, the still-beating challenge hearts had a spectrum from normal to severe chronic rejection that defined the tolerogenicity of the original primary grafts: liver best → bone marrow next → heart least. Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began. The tissue chimerism was invariably multilineage, but the GVHD outcome was associated with T cell over-representation. These observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients. The results are discussed in relation to the historical tolerance studies of Billingham, Brent, and Medawar; Good; Monaco; and Calne.

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“…However, this assumption was not supported by some of the earliest therapeutically relevant eJqleriments shoWlng that neither ~space" nor even immunosuppressIOn was required in adult mice for production of chlmensm and tolerance under specific cm:umstances that were largely determined by histocompatibility variables. In 1959, Mariani, Martinez, Smith, and Good (46) reported that adult splenocytes could induce chimerism and tolerance to skin grafts across the sex-linked Eichwald-Silmser histocompatibility difference in immunologically competent mature unconditioned syngeneic mice. Brent and Gowland (47) described the same thing in selected allogeneic mouse strain combinations, using frequent inoculations of very large numbers of cells.…”

Section: Discussionmentioning

confidence: 99%