Transfer of acquired tolerance to skin homografts in mice

Martínez, Carlos A.; Smith, Julius; Aust, J. Bradley; Mariani, T; Ra, Good

doi:10.1097/00006534-195810000-00052

Cited by 4 publications

(6 citation statements)

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“…Comparison of efforts to transfer tolerance to syngenic newborn mice from mice made tolerant with viable spleen cells and with disrupted spleen cell preparations supports our previous contention that long-lasting tolerance produced by injection of viable spleen cells is associated with persistence and replication of cells from the original donor (10,13,(17)(18)(19). The mice made tolerant either as adults or as neonates by injection of the disrupted spleen cell preparations revealed no capacity to transfer the tolerant state to syngenic newborn recipients.…”

Section: Discussionsupporting

confidence: 70%

“…studies from this laboratory have demonstrated that tolerance for allogenic tissue grafts induced in mice by the intravenous administration at birth of viable lymphoreticular cells can be transferred to syngenic individuals by injecting these animals during the newborn period with lymphoreficular cells derived from tolerant donors (17). Similar transfer of tolerance was achieved in newborn mice when the cells injected were derived from individuals made tolerant during adult life (13).…”

Section: Transfer Of Tolerance Induced By Treatment With Disrupted Cementioning

confidence: 90%

“…The total number of cells injected and the length of time during which parabiosis had to be maintained to bring about a permanent state of immunological unresponsiveness was found to be dependent on the genetic disparity between the donor and the host (16). Tolerance obtained by these methods may be transferred to isologous mice by injecting these animals at birth with a single intravenous injection of approximately 5 million viable spleen cells derived from tolerant donors (17)(18)(19). More recently Brent and Gowland (20)(21)(22) confirmed and extended our observations that immunological tolerance of allogenic skin grafts could be obtained in adult mice by repeated injections of a]logenic viable spleen cells.…”

mentioning

confidence: 99%

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Production of Immunological Tolerance in Mice After Repeated Injections of Disrupted Spleen Cells

Martínez

Smith

Blaese

et al. 1963

The Journal of Experimental Medicine

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1. Tolerance of male skin isografts has been regularly produced in female mice of the C57B1 strain sublines 1, 4, and 6 during adult life by repeated injection of completely disrupted spleen cells derived from male donors. The tolerant state is long-lasting since such grafts have remained in place more than 9 months. 2. Prolonged survival of homotransplants of skin has regularly been produced in DBA/2 mice during adult life by repeated injections of completely disrupted spleen cells from Balb/C donors. When injections of disrupted spleen cell material are continued over a sufficiently long period, permanent acceptance of the skin homografts may be obtained between these strains. 3. Immunological tolerance across even the strong H-2 histocompatibility barrier was obtained in the neonatal period and during adult life by repeated injection of disrupted spleen cell preparations. The tolerant state has been revealed by both mammary adenocarcinoma and skin homografting across this strong histocompatibility barrier. 4. In contradistinction to the tolerant state produced by injection of intact spleen cells in neonatal animals or during adult life or that produced by parabiotic union, the tolerance produced by repeated injection of disrupted spleen cell preparations cannot be transferred to syngenic neonatal mice with spleen cells of the tolerant animal. 5. The implications of these findings in transplantation biology and in consideration of the basic nature of tolerance are discussed.

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Section: Discussionsupporting

confidence: 70%

Section: Transfer Of Tolerance Induced By Treatment With Disrupted Cementioning

confidence: 90%

mentioning

confidence: 99%

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Production of Immunological Tolerance in Mice After Repeated Injections of Disrupted Spleen Cells

Martínez

Smith

Blaese

et al. 1963

The Journal of Experimental Medicine

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“…This phenomenon, known as the Eichwald-Silmser phenomenon, has been interpreted as being an immunologic process dependent on a genetic difference between male and female conditioned by the Y chromosome of the males of these strains of mice. Immunologic tolerance produced by intravenous injection of spleen cells into the females from the males either at birth (36,37) or in larger doses later in fife (38,39) argues strongly for the operation of immunologic processes in the rejection of male skin by females in these strains of mice.…”

Section: Acceptance Of Tumor Homografts Across the H-2 Histocompatibimentioning

confidence: 99%

The Role of the Thymus in Development of Immunologic Capacity in Rabbits and Mice

Good

Dalmasso

Martínez

et al. 1962

The Journal of Experimental Medicine

376

106

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Although the thymus gland has been known from antiquity, its role in the body economy has remained enigmatic until recently. During the past year, however, a flurry of reports have given the first indications of the role of this organ in developmental biology. In mammals the thymus develops from the third and fourth pharyngeal pouches in early embryonic life, reaches maximal relative size near the time of birth, and then undergoes a gradual involution. In man the thymus appears in the 10 mm embryo, reaches maximal relative size in the neonate, attains maximal absolute size in the 12-year-old child, and then ..... gradually decreases in relative and absolute size as maturity is reached (1).Our interest in the thymus developed in 1953 when we (2, 3) discovered that a patient with "acquired agammaglobulinemia" had developed a marked immunologic deficiency and an abnormality of the thymus--a benign thymoma--at about the same time. Removal of the thymoma, which was primarily an epithelial stromal overgrowth of the thymus pathologically, failed to alter either the protein abnormality or the immunologic defect. Since that time seven cases of the combined occurrence of these two disorders have been reported (4-8), and in no instance has removal of the thymic tumor restored immunologic function or the protein deficit. Nonetheless, it seems clear that the association of these two rare conditions has been far too frequent to be explained by chance alone.

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“…At the same time, successful organ homotransplantation was re ported by M artinez et al (17) by the first preliminary results that endocrine homografts retained functional capacities when placed in tolerant recipients. They observed that A strain ovaries maintained their function, as evidenced by vaginal epithelial cycles, when trans planted in to castrated Z Cefj recipients made tolerant with a subcutaneous injection, during the last stages of gestation, of spleen cells obtained from adult A strain mice.…”

Section: Acquired Tolerance and Organ / / Omotransplantationmentioning

confidence: 96%

Studies of Sex-Linked Histo-Incompatibility in Inbred Mice: Role of Age and Production of Immunological Tolerance

Mariani¹,

Martínez²,

Good³

1960

Int Arch Allergy Immunol

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Transfer of acquired tolerance to skin homografts in mice

Cited by 4 publications

References 0 publications

Production of Immunological Tolerance in Mice After Repeated Injections of Disrupted Spleen Cells

Production of Immunological Tolerance in Mice After Repeated Injections of Disrupted Spleen Cells

The Role of the Thymus in Development of Immunologic Capacity in Rabbits and Mice

Studies of Sex-Linked Histo-Incompatibility in Inbred Mice: Role of Age and Production of Immunological Tolerance

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