Studies of Sex-Linked Histo-Incompatibility in Inbred Mice: Role of Age and Production of Immunological Tolerance

Mariani, T; Martínez, Carlos A.; Good, R A

doi:10.1159/000229091

Cited by 6 publications

(1 citation statement)

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“…This phenomenon, known as the Eichwald-Silmser phenomenon, has been interpreted as being an immunologic process dependent on a genetic difference between male and female conditioned by the Y chromosome of the males of these strains of mice. Immunologic tolerance produced by intravenous injection of spleen cells into the females from the males either at birth (36,37) or in larger doses later in fife (38,39) argues strongly for the operation of immunologic processes in the rejection of male skin by females in these strains of mice.…”

Section: Acceptance Of Tumor Homografts Across the H-2 Histocompatibimentioning

confidence: 99%

The Role of the Thymus in Development of Immunologic Capacity in Rabbits and Mice

Good

Dalmasso

Martínez

et al. 1962

The Journal of Experimental Medicine

376

106

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Although the thymus gland has been known from antiquity, its role in the body economy has remained enigmatic until recently. During the past year, however, a flurry of reports have given the first indications of the role of this organ in developmental biology. In mammals the thymus develops from the third and fourth pharyngeal pouches in early embryonic life, reaches maximal relative size near the time of birth, and then undergoes a gradual involution. In man the thymus appears in the 10 mm embryo, reaches maximal relative size in the neonate, attains maximal absolute size in the 12-year-old child, and then ..... gradually decreases in relative and absolute size as maturity is reached (1).Our interest in the thymus developed in 1953 when we (2, 3) discovered that a patient with "acquired agammaglobulinemia" had developed a marked immunologic deficiency and an abnormality of the thymus--a benign thymoma--at about the same time. Removal of the thymoma, which was primarily an epithelial stromal overgrowth of the thymus pathologically, failed to alter either the protein abnormality or the immunologic defect. Since that time seven cases of the combined occurrence of these two disorders have been reported (4-8), and in no instance has removal of the thymic tumor restored immunologic function or the protein deficit. Nonetheless, it seems clear that the association of these two rare conditions has been far too frequent to be explained by chance alone.

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