The experience with cutaneous tuberculosis at Ga-Rankuwa Hospital is reviewed. A total of 92 cases of skin tuberculosis was seen over the past 12 years. All recognized forms of cutaneous tuberculosis were encountered, plus some forms which were difficult to classify. Lupus vulgaris was the most common true infection and papulonecrotic tuberculid the most common tuberculid. The classification and pathogenetic mechanisms are briefly discussed.
SUMMARY
A patient with post‐inflammatory cutis laxa and primary aortitis is described. Certain cases of primary aortitis or post‐inflammatory cutis laxa occurring per se can be considered as polar variations of the same disease.
SUMMARY.— The clinical records and the histopathology of 140 cases of naevus sebaceus and related compound epidermal naevi have been studied with special reference to the incidence of secondary tumours. In 27 lesions there were areas of syringocystadenoma papilliferum, sometimes forming a large part of the naevus. In 9 lesions, basal cell epithelioma was a secondary development, but only 3 of these epitheliomata showed evidence of an aggressive growth pattern. Fourteen other naevi were found histologically to have small areas of basaloid proliferation, but these proliferations were considered to be harnartomatous rather than epitheliomatous in nature. So far, on follow‐up, none of the basal cell epitheliomata has recurred after treatment.
A rare complication found in a patient aged 56 was the development of a squamous cell epithelioma which, although poorly differentiated, had not recurred 4 years after excision. Other related lesions were 3 syringomata, 2 apocrine cystadenomata and 2 osteomata. Some of the naevi showed areas of unusual squamous proliferation which were difficult to categorize histologically; in 2 instances keratoacanthomata were simulated; other proliferations showed “clear cell” differentiation or pseudo‐epitheliomatous hyperplasia. It was concluded from this study that there is only a small risk of a serious malignant tumour supervening in naevus sebaceus, and that simple surgical excision is usually adequate treatment.
SUMMARY
Four white South African families (9 patients) with lipoid proteinosis were genealogically investigated. All 4 families could be traced to a brother and sister who came from Germany and settled in South Africa in the seventeenth century.
The dermatological findings in five patients with thallium poisoning are described. Cutaneous involvement consisted mainly of an acneiform eruption, pellagra-like dyssebacea, crusted eczematous lesions and dry scaling of the distal parts of the extremities. Alopecia was not evident initially but later became apparent. The patients also had gastrointestinal and neurological symptoms and signs.
A genealogical study of lipoid proteinosis indicates that most, if not all, South African patients are probably descendants of a brother and sister, Jacob and Elsje Cloete, who settled in the Cape early in the latter half of the 17th century. It is suggested that a similar genealogical study be undertaken of patients in other countries to see whether more of them could be traced to the same family.
The clinical and histologic features of sucking pads in neonates are clearly different from sucking blisters and leukoedema, both of which may also be present in neonates. We propose that the condition is due to a combination of intracellular edema and hyperkeratosis. Perhaps the alternative term of sucking calluses is more appropriate. The intracellular edema is ascribed to passive diffusion of fluid, presumably saliva, into the cells, while the hyperkeratosis is regarded as an adaptive phenomenon to friction during sucking.
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