Thallium poisoning: a dermatological perspective

Heyl, T.; Barlow, R.J.

doi:10.1111/j.1365-2133.1989.tb08223.x

Cited by 23 publications

(17 citation statements)

References 6 publications

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“…Dermatological manifestations including the characteristic alopecia that occurs after the second week of poisoning, scaling of the palms and soles, Mees' lines (white transverse bands on the nails), acneform lesions, loss of the lateral third of eyebrows, hair discoloration and eczematous rash were seen in our patients. These manifestations are thought to occur due to secondary deficiency of riboflavin [6,11]. None of our cases developed palmar erythema.…”

Section: Discussionmentioning

confidence: 87%

Acute Thallium Poisoning: Series of Ten Cases

et al. 2011

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Section: Discussionmentioning

confidence: 87%

Acute Thallium Poisoning: Series of Ten Cases

et al. 2011

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“…Rusyniak et al 386 their hair in clumps [182,185,187]. By 2-3 weeks patients may have developed total body alopecia -including axillary hair, pubic hair, and the lateral eyebrows [192][193][194]. The medial part of the eyebrow is typically spared as these hairs are commonly in a resting non-growth phase [194,195].…”

Section: Clinical Presentationmentioning

confidence: 97%

Heavy metal poisoning: management of intoxication and antidotes

Rusyniak

Arroyo

Acciani

et al. 2010

Experientia Supplementum

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Abstract. Of the known elements, nearly 80% are either metals or metalloids. The highly reactive nature of most metals result in their forming complexes with other compounds such oxygen, sulfide and chloride. Although this reactivity is the primary means by which they are toxic, many metals, in trace amounts, are vital to normal physiological processes; examples include iron in oxygen transport, manganese and selenium in antioxidant defense and zinc in metabolism. With these essential metals toxicity occurs when concentrations are either too low or too high. For some metals there are no physiological concentrations that are beneficial; as such these metals only have the potential to cause toxicity. This chapter focuses on four of these: arsenic, mercury, lead and thallium.

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“…Alopecia is a typical symptom of thallium poisoning, usually occurring by the second week after intoxication (Heyl & Barlow 1989). Hair loss affects the scalp, the eyelashes, lateral aspects of the eyebrows, and the arms and legs.…”

Section: Thallium and Mercury Poisoningmentioning

confidence: 99%

Drug-Induced Hair Loss and Hair Growth

et al. 1994

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A large number of drugs may interfere with the hair cycle and produce hair loss. Drugs may affect anagen follicles through 2 main different modalities: (i) by inducing an abrupt cessation of mitotic activity in rapidly dividing hair matrix cells (anagen effluvium) or (ii) by precipitating the follicles into premature rest (telogen effluvium). In anagen effluvium, hair loss usually occurs within days to weeks of drug administration, whereas in telogen effluvium, hair loss becomes evident 2 to 4 months after starting treatment. Anagen effluvium is a prominent adverse effect of antineoplastic agents, which cause acute damage of rapidly dividing hair matrix cells. Telogen effluvium may be a consequence of a large number of drugs including anticoagulants, retinol (vitamin A) and its derivatives, interferons and antihyperlipidaemic drugs. Drug-induced hair loss is usually reversible after interruption of treatment. The prevalence and severity of alopecia depend on the drug as well as on individual predisposition. Some drugs produce hair loss in most patients receiving appropriate dosages while other drugs are only occasionally responsible for hair abnormalities. Both hirsutism and hypertrichosis may be associated with drug administration. Drugs most commonly responsible for the development of hirsutism include testosterone, danazol, corticotrophin (ACTH), metyrapone, anabolic steroids and glucocorticoids. Hypertrichosis is a common adverse effect of cyclosporin, minoxidil and diazoxide.

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Thallium poisoning: a dermatological perspective

Cited by 23 publications

References 6 publications

Acute Thallium Poisoning: Series of Ten Cases

Acute Thallium Poisoning: Series of Ten Cases

Heavy metal poisoning: management of intoxication and antidotes

Drug-Induced Hair Loss and Hair Growth

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