Naevus Sebaceus.

Abstract

SUMMARY.— The clinical records and the histopathology of 140 cases of naevus sebaceus and related compound epidermal naevi have been studied with special reference to the incidence of secondary tumours. In 27 lesions there were areas of syringocystadenoma papilliferum, sometimes forming a large part of the naevus. In 9 lesions, basal cell epithelioma was a secondary development, but only 3 of these epitheliomata showed evidence of an aggressive growth pattern. Fourteen other naevi were found histologically to have small areas of basaloid proliferation, but these proliferations were considered to be harnartomatous rather than epitheliomatous in nature. So far, on follow‐up, none of the basal cell epitheliomata has recurred after treatment. A rare complication found in a patient aged 56 was the development of a squamous cell epithelioma which, although poorly differentiated, had not recurred 4 years after excision. Other related lesions were 3 syringomata, 2 apocrine cystadenomata and 2 osteomata. Some of the naevi showed areas of unusual squamous proliferation which were difficult to categorize histologically; in 2 instances keratoacanthomata were simulated; other proliferations showed “clear cell” differentiation or pseudo‐epitheliomatous hyperplasia. It was concluded from this study that there is only a small risk of a serious malignant tumour supervening in naevus sebaceus, and that simple surgical excision is usually adequate treatment.

Nevus Sebaceous Accompanying Secondary Neoplasms and Unique Histopathologic Findings

“…Syringocystadenoma papilliferum has been found in 8% to 19% of NS1. Basaloid epithelial proliferations have been clinically evident in 5% to 7% of NS5. In the current case, syringocystadenoma papilliferum and trichoblastoma-like lesions arising from the NS were observed.…”

Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report

“…This low risk of malignancy is in contrast to nevus sebaceus, which is more frequently associated with the development of malignant tumors. [2223]…”

“…ILVEN can be distinguished because of its earlier onset and lack of spontaneous regression. [4] Lesions are potentially premalignant with a 15–20% risk of malignant transformation,[22] hence the early surgical removal of these lesions should be considered. Patients with extensive epidermal nevi and systemic abnormalities should be suspected of having the epidermal nevus syndrome.…”

Development of Six Tumors in a Sebaceus Nevus of Jadassohn: Report of a Case

“…Mehregan and Pinkus7 described a series of 150 patients with NS, including 4 that had three coexisting tumors and one that had 4 tumors. In another series of 140 patients with NS, Jones and Heyl8 found only 1 patient with 3 tumors.…”