The objective of this study was to test the hypothesis that ischemia reperfusion damage in kidney transplantation is associated with lipid peroxidation and that inhibition of lipid peroxidation by antioxidants improves the function of the transplanted kidney. Lipid peroxidation was assessed by measuring the plasma malonaldehyde content (as thiobarbituric acid reaction product) with high-performance liquid chromatography. Kidney function was assessed by plasma creatinine and creatinine clearance. Thirty patients of an ongoing series were randomly selected into two groups, with 14 controls and 16 patients in the antioxidant therapy group. Therapy consisted of two ampoules of Omnibionta (which contains vitamins C, E, A and B complex) diluted in 500 ml physiological sodium chloride, which was infused intravenously prior to reperfusion onset. No significant differences existed for the age of the patients in the control (43.00 +/- 9.86 years) and the therapy group (41.56 +/- 14.14 years) nor in the kidney preservation time, which was 24.12 +/- 8.73 and 18.43 +/- 9.97 hours in the control and therapy group, respectively. The controls showed a transient increase of plasma lipid peroxides as measured by malonaldehyde with a peak one hour after onset of reperfusion. Compared to the baseline value of 0.74 +/- 0.26 (mean +/- SD) the one hour malonaldehyde value increased to 1.46 +/- 0.22 nmol/ml (P < 0.001). In the therapy group the plasma malonaldehyde level did not increase, but slightly decreased by about 20% compared to the baseline value. The difference of plasma malonaldehyde between the two groups one hour after reperfusion onset was highly significant (P > 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
Objective To report the results of transurethral submu-Results After a mean follow-up of 15.5 months, five patients, who suCered from day and night inconticosal injection therapy of polydimethylsiloxane (PDS) to treat incontinence after radical prostatectomy (RP).nence and required at least five pads per day, were dry after injection therapy. One patient improved Patients and methods Since 1993, about 80 retropubic RPs have been carried out at our institution each significantly but still required two pads during the day, but was continent during the night; three patients year. Severe post-operative incontinence occurred in six patients, with a mean duration of incontinence required a second injection. A mean of 7.5 mL of PDS was used per patient and the side-eCects of therapy after RP of 28 months. The pre-operative evaluation consisted of cysto-urethroscopy and urodynamics.(dysuria and urinary retention) were minimal. Conclusion Because PDS has excellent biocompatibility, Because we have no experience with artificial sphincter implantation, transurethral injection therapy was few side-eCects or complications, transurethral injection therapy using silicone particles is a justifiable used to treat the post-operative incontinence, using PDS (vulcanized silicone rubber particles). This mateprocedure for treating incontinence after RP. Keywords Radical prostatectomy, post-operative inconrial has a mean particle size of 188 mm, providing stability of the material at the injection site. The six tinence, transurethral submucosal injection, polydimethylsiloxane patients with severe post-operative incontinence were treated using injection therapy with PDS. various materials, e.g. PTFE, collagen, fat or silicone
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