Human plasma lipid peroxide levels show a strong transient increase after successful revascularization operations

Rabl, Hans; Khoschsorur, G.; Colombo, T.; Tatzber, Franz; Esterbauer, H.

doi:10.1016/0891-5849(92)90175-g

Cited by 61 publications

(21 citation statements)

References 29 publications

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“…The role of reactive oxygen species in human kidney transplantation seems to correlate with results obtained in animal studies. In human renal transplantation studies, increases in myeloperoxidase and lipid peroxide product levels have been demonstrated in the blood of the transplant recipients following revascularization [13][14][15]. In this study, we have investigated whether TMZ has a protective effect on renal tissue subjected to IR injury.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of Trimetazidine on 75 min Warm Renal Ischemia-Reperfusion Injury in Rats

et al. 1998

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In this experimental study, we evaluated the effect of trimetazidine (TMZ) on renal ischemia-reperfusion (IR) injury in Sprague-Dawley rats. Renal IR was achieved by a 75-min clamping of the left renal pedicle and subsequent 24 h reperfusion, after right nephrectomy was performed. The rats were randomly divided into three groups: group 1 (sham operated: no IR injury), group 2 (ischemic control: saline treatment), and group 3 (3 mg/kg TMZ before ischemia). After 24 h of reperfusion, blood samples and renal tissue samples were taken to measure the levels of creatinine, tissue malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) activity. Histopathological changes were evaluated. In addition, the 7-day survival rates in each group were evaluated. We found significant increases in the levels of creatinine and tissue MDA, severe acute tubular necrosis, and a significant decrease in the activity of the GSH-Px in group 2. There were significant decreases in the levels of creatinine and tissue MDA, mild acute tubular necrosis, and a significant increase in activity of the GSH-Px in group 3 when compared with the control group (p <0.05). Statistically significant differences (p <0.05) in survival were noted between the ischemic control and sham-operated and TMZ groups. We have concluded that TMZ is able to protect the kidney from warm IR injury.

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Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of Trimetazidine on 75 min Warm Renal Ischemia-Reperfusion Injury in Rats

et al. 1998

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“…As oxygen free radicals are responsible for oxidative damage of tissues exposed to ischaemia [21], it was unsurprising to know that during balloon angioplasty of peripheral arteries, LPO, a marker of oxidative stress, was markedly increased following balloon inflation compared to baseline [14]. Another study demonstrated that peripher-al blood showed a transient increase in markers of lipid peroxidation following successful surgery for limb salvage at intervals of 11 h after reperfusion [15]. Nevertheless, one study by Hafez et al [16] failed to demonstrate a similar rise in patients undergoing abdominal aortic aneurysm repair.…”

Section: Discussionmentioning

confidence: 99%

“…Oxygen free radicals are responsible for oxidative damage of tissues exposed to ischaemia, although the changes following balloon angioplasty and surgery for PVD have been conflicting [14][15][16]. It remains uncertain whether the changes in oxidative stress contribute to abnormal thrombogenesis following vascular surgery.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Thrombogenesis, Endothelial Damage and Oxidative Stress with Reperfusion during Femoral Artery Bypass Surgery for Peripheral Vascular Disease

Makin

Chung

Silverman

et al. 2002

Pathophysiol Haemos Thromb

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Peripheral vascular disease (PVD) is a significant cause of cardiovascular morbidity. We hypothesised that there would be significant alterations of thrombogenesis, platelet activation and endothelial damage, which could be associated with abnormal oxidative stress during femoral artery bypass surgery for PVD, where the femoral artery is cross-clamped (causing acute ischaemia) and reperfused (following revascularisation). To test this hypothesis, we measured sequential changes in von Willebrand factor (vWF, and index of endothelial damage/dysfunction), tissue factor (TF, an index of thrombogenesis) and soluble P-selectin (sP-sel, an index of platelet activation) as well as lipid hydroperoxides (LPO, an index of oxidative stress) in 28 consecutive patients undergoing elective peripheral artery bypass surgery. Mean baseline vWF and sP-sel levels in PVD patients (before clamping) were significantly higher compared with age- and sex-matched controls (unpaired t test, both p < 0.05), but there were no significant differences in TF and LPO levels. There was a correlation between TF and vWF (Spearman’s, r = 0.374, p = 0.05), as well as between sP-sel and vWF at the start of surgery (r = 0.467, p = 0.012). The patients undergoing peripheral artery bypass surgery had a mean femoral artery clamp time of 28 min (standard deviation 14 min; range 11–65 min). There were no significant overall changes in sP-sel, vWF, TF and LPO with femoral artery cross-clamping and reperfusion (repeated measures ANOVA, p = NS). In conclusion, we found that during ischaemia-reperfusion during peripheral arterial bypass surgery, thrombogenesis (as measured by plasma TF) and oxidative damage (as measured by LPO) within the affected leg does not increase in the immediate perioperative period. Further studies are required to assess the mechanism(s) of ischaemia-reperfusion injury in PVD, and the contributory role(s) of the endothelium and platelets.

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“…Aliquots of 10 ml blood were centrifuged and serum samples were stored at -24°C till later analysis. Oxygen free radical mediated lipid peroxidation was determined from the same aliquots that were used for the determination of clinical tumor markers [12][13][14][15][16].…”

Section: Methodsmentioning

confidence: 99%

Lipid Peroxidation as Additional Marker in Patients with Colorectal Cancer

Lauschke

Tolba²,

Burger³

et al. 2002

Eur Surg Res

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Background and Aims: Up to now, various tumor markers have been proposed for the detection of the onset of malignant cell transformation or the better follow-up of cancer patients. The aim of the present study is to investigate the diagnostic value of systemic lipid peroxidation as an additional evaluative tool in the follow-up of surgical patients with colorectal cancer in combination to the clinically routine tumor markers carcinoembryonic antigen (CEA) and carcinoantigen 19-9 (CA 19-9). Patients and Methods: 36 patients with a colorectal carcinoma were included in this study. Blood samples were collected 1 day prior to the operation, 10 days and 1 year after the operation. Oxygen free radical mediated lipid peroxidation was determined by measurement of thiobarbituric acid-reactive substances in the same serum that were used for the determination of tumor markers. Results: Compared to control values, a highly significant increase of lipid peroxidation was found in the serum of all colorectal carcinoma patients up to the first 10 postoperative days. Differentiation of the patients, according to the T-stage, showed a marked and more obvious tendency towards higher serum lipid peroxides with increased tumor stage when compared to the conventional tumor markers. One year postoperatively the serum levels of lipid peroxidation returned to nearly normal values. Also the conventional tumor markers CEA and CA 19-9 showed a relative rise in the levels with the respective tumor stage, but differences were only statistically significant in the highest T-categories. Conclusion: After curative resection of the tumor, the level of systemic lipid peroxides decreases to normal values. We conclude from these results that the tumor is the primary cause of the increased systemic lipid peroxides.

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Human plasma lipid peroxide levels show a strong transient increase after successful revascularization operations

Cited by 61 publications

References 29 publications

Cytoprotective Effect of Trimetazidine on 75 min Warm Renal Ischemia-Reperfusion Injury in Rats

Cytoprotective Effect of Trimetazidine on 75 min Warm Renal Ischemia-Reperfusion Injury in Rats

Alterations of Thrombogenesis, Endothelial Damage and Oxidative Stress with Reperfusion during Femoral Artery Bypass Surgery for Peripheral Vascular Disease

Lipid Peroxidation as Additional Marker in Patients with Colorectal Cancer

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