The use of polydimethylsiloxane in the treatment of incontinence after radical prostatectomy

Abstract

Objective To report the results of transurethral submu-Results After a mean follow-up of 15.5 months, five patients, who suCered from day and night inconticosal injection therapy of polydimethylsiloxane (PDS) to treat incontinence after radical prostatectomy (RP).nence and required at least five pads per day, were dry after injection therapy. One patient improved Patients and methods Since 1993, about 80 retropubic RPs have been carried out at our institution each significantly but still required two pads during the day, but was continent during the night; three patients year. Severe post-operative incontinence occurred in six patients, with a mean duration of incontinence required a second injection. A mean of 7.5 mL of PDS was used per patient and the side-eCects of therapy after RP of 28 months. The pre-operative evaluation consisted of cysto-urethroscopy and urodynamics.(dysuria and urinary retention) were minimal. Conclusion Because PDS has excellent biocompatibility, Because we have no experience with artificial sphincter implantation, transurethral injection therapy was few side-eCects or complications, transurethral injection therapy using silicone particles is a justifiable used to treat the post-operative incontinence, using PDS (vulcanized silicone rubber particles). This mateprocedure for treating incontinence after RP. Keywords Radical prostatectomy, post-operative inconrial has a mean particle size of 188 mm, providing stability of the material at the injection site. The six tinence, transurethral submucosal injection, polydimethylsiloxane patients with severe post-operative incontinence were treated using injection therapy with PDS. various materials, e.g. PTFE, collagen, fat or silicone

The normal post-surgical anatomy of the male pelvis following radical prostatectomy as assessed by magnetic resonance imaging

“…In patients suffering post-operative incontinence, silastic or similar agents can be injected around the urethral sphincter mechanism in order to act as a bulking agent [28]. This appearance should not be confused with recurrent or residual disease (Fig.…”

Textured polydimethylsiloxane elastomers in the human larynx: Safety and efficiency of use

“…[5][6][7] Occasional use of PDMS in laryngology was published 8 in the European literature in 1993. We report for the first time the long-term results of injection laryngoplasty using PDMS elastomers on a limited number of patients.…”

The use of urethral bulking injections in post‐prostatectomy stress urinary incontinence: A narrative review of the literature

“…There exist many contradictory reports (Table ), resulting in a wide range of data and a high standard deviation (SD 23.65). Reports of extremes of values (SD away from the mean) are associated with smaller populations (N < 20) and the first reported use of new BA …”

“…Reports of extremes of values (≥SD away from the mean) are associated with smaller populations (N < 20) and the first reported use of new BA. 12,14,20,28,33 The general level of evidence for the use of BA in PPI was considered low by the European Association of Urology (Level 3, Recommendation grade C). 35 The only Cochrane systematic review 36 on the subject cited one RCT.…”