SEVERAL reports have appeared concerning the stereochemistry of hydrogen elimination during double bond formation in various stero1s.l We have described1"Pd the stereochemistry of hydrogen elimination from C-22 and C-23 during introduction of the 22-trans-double bond into poriferasterol by the phytoflagellate, Ochronzonas nzalhamensis. \T-e used mevalonic acid (MV-4) labelled stereospecifically with tritium a t either C-2 or C-5. We now describe the results of similar studies on the biosynthesis of ergosterol by Aspergilrzbs fuunigatws Fres., and show an interesting and unexpeci;ed difference between this fungus and the alga, 0. mali umensis, in the stereochemistry of hydrogen eliminat: ons during the elaboration of the 22-double bond.
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