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Silver nanoparticles stabilized by soluble starch were synthesized and characterized. In vivo studies in rats showed no toxicity and revealed their distribution in various tissues and permeability across BBB. This starch stabilized silver nanoparticles have good biological characteristics to act as a potential promising vector for gene/drug delivery.

Nanotechnology has shown significant promise in development of drugs and drug delivery systems that can overcome all limitations and address urgent needs to improve efficacy of diagnosis and therapy of various diseases including cancer. The functionalization with neem compounds as synthesis and capping agent had shown very high anticancer activities against Gastric cancer cells in vitro. The biochemical factors like albumin, glucose, and DNA concentrations were modulated along with Protease inhibitor and Catalase activates, the various cancer specific proteins like p53, GRD 70-78 kDa and other proteins of sizes 35-40 kDa corresponding to H+K+ATPase protein etc. The apoptic activity and antiproliferative activity were demonstrated with Gastric cancer cells in vitro.

The incidence of acute kidney injury and disease is increasing alarmingly. Inflammatory or nutritional status are associated with kidney disease/ Serum albumin is the marker to identify malnutrition in patients with chronic kidney disease. Treatment with albumin functionalized green synthesized silver nanoparticles help maintain and restore normal cellular function in the kidney. The role of albumin in kidney cell metabolism was studied in-vitro and showed a profound influence of albumin with or without nanoparticles on the level of protein, glucose, and catalase activity. The albumin-nanoparticle treated cells were observed to be healthier as evidenced from the morphology of the cells. Elevated levels of 66 kDa, 59 kDa, 45 kDa, 34, 29 kDa proteins were observed. The proteins may be Heat shock proteins which has cytoprotective properties. The antimicrobial properties of the silver nanoparticles control the infection and inflammation. This novel nanopreparation could lead to the new therapeutics in the treatment of renal injury restoring renal function. Research highlight• Hypoalbuminemia, is highly prevalent in kidney failure and is associated with an increased mortality risk reflecting either the inflammatory or nutritional status of patients• To understand the relationship between malnutrition and serum albumin dosed through functionalized silver nanoparticles the current study was carried out in patients with illness and in organ culture using mice kidney in vitro.• The Albumin functionalized silver nanoparticles were effective combating inflammation and degradation of cellular and extracellular matrix, transporting nutrition to the damaged nephrons prompting self-repair to maintain the status of protein and fat metabolism to avoid dialysis and to support the kidney to work properly preventing acute renal failure.• Besides, the nanoformulation strengthen the immune system to fight chronic problems reducing the oxidative stress and infection preventing acute renal failure.