Therapeutic Potential of Neem Synthesized Silver Nanoparticles on Human Gastric Cancer Cells &amp;lt;i&amp;gt;in Vitro&amp;lt;/i&amp;gt;

Sironmani, T. Anitha

doi:10.4236/wjnse.2016.62010

Cited by 6 publications

(5 citation statements)

References 137 publications

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“…Additionally, this meliaceae plant has unique agro-medicinal properties. Since, parallel to its efficacy as a bio-pesticide it also instills immunomodulatory (Goswami et al, 2016 ), anti-cancer (Sironmani, 2016 ), anti-microbial (Verma and Mehata, 2016 ), and wound healing (Bhagavathy and Kancharla, 2016 ) properties, which can pave way to an interdisciplinary approach by integrating the attributes of this plant to provide multiple benefits in agriculture as well as in biomedicine.…”

Section: Future Perspectivementioning

confidence: 99%

Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides

et al. 2017

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Over the years, extensive use of commercially available synthetic pesticides against phytophagous insects has led to their bioaccumulation in the environment causing increased resistance and reduction in soil biodiversity. Further, 90% of the applied pesticides enter the various environmental resources as a result of run-off, exposing the farmers as well as consumers of the agricultural produce to severe health issues. Therefore, growing attention has been given toward the development of alternate environmentally friendly pesticides/insecticides that would aid an efficient pest management system and also prevent chronic exposures leading to diseases. One such strategy is, the use of neem plant's (Binomial name: Azadirachta indica) active ingredients which exhibit agro-medicinal properties conferring insecticidal as well as immunomodulatory and anti-cancer properties. The most prominent constituent of neem is azadirachtin, which has been established as a pivotal insecticidal ingredient. It acts as an antifeedant, repellent, and repugnant agent and induces sterility in insects by preventing oviposition and interrupting sperm production in males. This review discusses, key neem pesticidal components, their active functional ingredients along with recent strategies on employing nanocarriers, to provide controlled release of the active ingredients and to improve their stability and sustainability.

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Section: Future Perspectivementioning

confidence: 99%

Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides

et al. 2017

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“…In vitro study, using neem compounds as a synthesis and capping agent to functionalize stomach cancer cells exhibited very high anticancer activity. In vitro apoptosis and antiproliferative properties were demonstrated using gastric cancer cells (Sironmani, 2016). During the pre-initiation stage stomach carcinogenesis in rats, the effects of aqueous extracts of neem on stomach carcinogenesis were investigated.…”

Section: Gastric or Stomach Cancermentioning

confidence: 99%

Therapeutic role of neem (Azadirachta indica Adr. Juss.) in different types of cancer: A systematic review

Azam

Khan

Lodhi

et al. 2023

Int. J. Appl. Exp. Biol.

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Azadirachta indica constituents exhibit potential therapeutic role to control cancer progression. The potential anti-cancerous activity of neem extracts reduces cell propagation, migration, inflammation, and invasion. The current review describes the importance and effectiveness of neem extracts in different solvents against various cancers. Studies performed in different geographic locations from 2001 to 2021 were searched in Google, PubMed, Google Scholar, and NCBI. The relevant information has been retrieved, including the type of extracts, solvents, year of publication, and type of cancers. A total of 125 relevant studies published in different journals have been screened, among which the most commonly used neem part was leaf (n = 79), followed by seed (n = 18), flower (n = 10), oil (n = 10), bark (n = 10), roots (n = 6), fruit (n = 6), gum (n = 5), limonoids (n = 5), nimbolide (n = 4), stem (n = 4), xylem (n = 1), and as herb (n = 1). Similarly, the most commonly investigated cancer to be treated with the neem extract was breast cancer (n = 23), followed by cancerous cell lines (n = 21), prostate cancer (n = 11), and leukemia (n = 8). Most of the studies applied ethanol (n = 40) as a solvent for neem extraction, followed by methanol (n = 25), distilled water (n = 17), ethyl acetate (n = 6), Gibco Dulbecco's Modified Eagle Medium (n = 4), 7,12-dimethylbenz[a]anthracene (n = 4), MTT assay (n = 3), acetone (n = 3), ether (n = 3), ethyl alcohol (n = 2), hexane (n = 2), glucose (n = 2), oxadiazol-2yl-benzothiazole (n = 2), and N-nitrosodiethylamine (n = 1). In conclusion, neem is an important medicinal plant with therapeutic potency against different types of cancer. However, its role has not been investigated widely in some cancers, including bone cancer, retinoblastoma, and oral cancer. Moreover, its potential role may be enhanced if nanocarriers are conjugated to prevent them from human enzymatic metabolism and for successful targeted delivery in cancer therapy.

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“…There are reports on the gastroprotective effect of nanoparticles synthesized by green technology; however, the gastroprotective effect was mediated through the inhibition of Helicobacter pylori [14] and modulation of apoptotic pathway [15]. The proton pump inhibition by nanoparticles has not been established, and thus this study of proton pump inhibition by the nanosilver biosynthesized using a plant extract is novel and the in vivo gastroprotective effect of these nanosilver particles needs to be validated.…”

Section: Proton Pump Inhibition By Agnps Synthesized Using Aesementioning

confidence: 99%

Evaluation of in Vitro Inhibition of Proton􀇧pump by Nanosilver Particles Synthesized Using Seeds of Anethum Graveolens

Menaga

Sangeetha

2017

Asian J Pharm Clin Res

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Objective: The green synthesis of nanoparticles is gaining popularity owing to its several advantages over the chemical methods. This study reports the biosynthesis of nanosilver mediated by the extract of the seeds of Anethum graveolens.Methods: Green synthesis of silver nanoparticles (AgNPs) was carried out using the aqueous extract of the seeds of A. graveolens (AESE). Microwave irradiation was done to hasten the process. The AgNPs synthesized were physically characterized using ultraviolet-visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The potential of the nanosilver particles in inhibiting H + K + adenosine triphosphatase (proton pump) was evaluated. Results:The nanosilver particles were initially subjected to characterization studies to ascertain their shape, size and surface composition. The particles were found to be crystalline, spherical of size 30-35 nm. The nanosilver particles inhibited the activity of proton pump by 67 % and thus were as potential as the standard drug, omeprazole. Conclusion:The seeds have several pharmacological benefits including its gastroprotective potential and hence the nanosilver particles synthesized using AESE was assessed for its gastroprotective potential. The results of this study prove that the nanosilver synthesized by green technology can inhibit proton-pump and thus act as promising gastroprotective agents.

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Therapeutic Potential of Neem Synthesized Silver Nanoparticles on Human Gastric Cancer Cells <i>in Vitro</i>

Cited by 6 publications

References 137 publications

Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides

Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides

Therapeutic role of neem (Azadirachta indica Adr. Juss.) in different types of cancer: A systematic review

Evaluation of in Vitro Inhibition of Proton􀇧pump by Nanosilver Particles Synthesized Using Seeds of Anethum Graveolens

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