Objective: The aim of the present investigation was to form matrix type transdermal patches containing imipramine hydrochloride were prepared using two polymers by solvent evaporation technique to minimise the dose of the drug for lesser side effect and increase the bioavailability of a drug. Methods:In the present study, drug loaded matrix type transdermal films of imipramine hydrochloride were prepared by the solvent evaporation method with the help of polymers along with polyethene glycol (PEG) 400 was used as plasticizer and dimethyl sulfoxide (DMSO) was used as penetration enhancer. Drug-polymer interactions determine by FTIR and a standard calibration curve of imipramine hydrochloride was determined by using UV estimation. Results:The formulated transdermal patch by using PVP K-30, HPMC K100M showed good physical properties. All prepared formulations indicated good physical stability. The formulation F-1 gave the most suitable transdermal film with all desirable physicochemical properties. The thickness of the patches was varied from 0.263±0.67 mm to 0.301±0.61 mm, uniformity of patches showed that patches prepared by solvent evaporation while low standard deviation values ensued by thickness measurements of the film, and weights ranged between 50.5±0.75 mg and 52.15±2.15 mg, which indicates that different batches patch weights, were comparatively similar. Folding endurance was found to be>200 that is satisfactory for the patches, drug content was found to be 5.33±0.14 mg to 5.57±0.095 mg. In vitro, drug permeation studies of formulations were performed by using K-C diffusion cells using abdomen skin of the albino rat. The results were best in in-vitro skin permeation through rat skin as compared to all other formulations prepared with a hydrophilic polymer containing permeation enhancer. The formulation, F1 is considered as the best formulation, since it shows maximum in vitro drug release as 84.71±3.07 % at 24 h. The drug release kinetics studies showed that the majority of formulations were governed by Higuchi model and mechanism of release was non-Fickian mediated. Conclusion:In conclusion, controlled release transdermal drug delivery system (TDDS) patches of imipramine hydrochloride can be prepared using the polymer combinations, with plasticizer and enhancer. The release rate of drug through patched increased simultaneously as the concentration of hydrophilic polymer was increased. However, the mechanism of drug release of all formulations was non-Fickian. The properties of a film did not change during the period of study.
The present study aimed to evaluate the phenolic compounds and in vitro antioxidant properties of ethanolic extract and selected fraction of Mimosa hamata whole plant. Phytochemical analysis of the extract of M. hamata indicated the presence of phenols and flavonoids in plant. The highest total phenolic and flavonoid content was observed in the IG fraction of M. hamata (654.33 ± 0.008 mg/g and 689.66 ± 0.032 mg/g respectively) in comparison to other fractions. The present investigation showed that ethanolic extract and fraction of M. hamata at various concentrations have good antioxidant capacity. Therefore, the overall results of the present studies were indicated that these bioactive compounds have been of interest for health benefits, the present analytical study proved a potential application to identify and quantify the phenolic compounds in plant extract and fractions.
Depression is a widespread psychiatric disorder affecting around 5% population of the world. It is fourth leading cause of disease trouble universal by ranked and it is expected to turn into the second most immobilizing disorder. Moreover, it is not easy to expect which patient will retort to whichever given treatment. At present obtainable antidepressant drugs are effective and harmless, but limitations range from a delayed start of action t o a considerable rate of non-responders. In the systems of traditional medicine, numerous plants and formulations have been used to take care of depression for thousands of years. We have reported antidepressant activity of EG. Therefore, the present study was start to evaluate the antidepressant potential of fruit extract of Elaeocarpus ganitrus and fraction of Elaeocarpus ganitrus in forced swim test (FST) and tail suspension test (TST). The mice were divided into six groups, each group containing five animals. Test drug Elaeocarpus ganitrus (EG) were suspended in distilled water. The vehicle (10ml/kg, p.o), Imipramine HCl (10mg/kg, p.o), EGE and EGF (50mg/kg, 100mg/kg, 150mg/kg and 200mg/kg, p.o. respectively) were administered 1 hour prior to study. Duration of immobility was noted in both the models. In our study, Imipramine HCl, EGE and EGF significantly reduced the duration of immobility in both experimental models as compared to the animals in the control gr oup. The antidepressant activity of EGE and EGF were comparable to that of standard drug Imipramine HCl. The results of the present study indicate the potential for use of EG as an adjuvant in the treatment of depression.
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