Study and Evaluation of Antidepressant Like Property of Ethanolic Seed Extract of Elaeocarpus Ganitrus in Animal Model of Depression

Abstract

Depression is a widespread psychiatric disorder affecting around 5% population of the world. It is fourth leading cause of disease trouble universal by ranked and it is expected to turn into the second most immobilizing disorder. Moreover, it is not easy to expect which patient will retort to whichever given treatment. At present obtainable antidepressant drugs are effective and harmless, but limitations range from a delayed start of action t o a considerable rate of non-responders. In the systems of traditional medicine, numerous plants and formulations have been used to take care of depression for thousands of years. We have reported antidepressant activity of EG. Therefore, the present study was start to evaluate the antidepressant potential of fruit extract of Elaeocarpus ganitrus and fraction of Elaeocarpus ganitrus in forced swim test (FST) and tail suspension test (TST). The mice were divided into six groups, each group containing five animals. Test drug Elaeocarpus ganitrus (EG) were suspended in distilled water. The vehicle (10ml/kg, p.o), Imipramine HCl (10mg/kg, p.o), EGE and EGF (50mg/kg, 100mg/kg, 150mg/kg and 200mg/kg, p.o. respectively) were administered 1 hour prior to study. Duration of immobility was noted in both the models. In our study, Imipramine HCl, EGE and EGF significantly reduced the duration of immobility in both experimental models as compared to the animals in the control gr oup. The antidepressant activity of EGE and EGF were comparable to that of standard drug Imipramine HCl. The results of the present study indicate the potential for use of EG as an adjuvant in the treatment of depression.

Phenological growth stages of sacred Elaeocarpus ganitrus Roxb. ex G. Don (Rudraksha) using the extended Biologische Bundesanstalt, Bundessortenamt und Chemische Industrie scale

“…Around 350 species of E . ganitrus (Lal, 2013) can be found from Madagascar in the west to India, Malaysia, Southeast Asia, Southern China and Japan in the east, and from Australia to New Zealand, Fiji, and Hawaii in the west (Hardainiyan et al, 2015). Elaeocarpus ganitrus is mainly grown from the Gangetic plains to the foothills of the Himalayas in India for its beads and therapeutical characteristics (Tripathi et al, 2015).…”

Phytochemical Screening and Comparative Antioxidant Potential of Different Extracts Isolated From E. Ganitrus Leaves

“…The phytochemical examination of Elaeocarpus species revealed the presence of a variety of desirable bioactive compounds, including indolizilidine alkaloids, triterpenes, tannins such as geraniin, 3,4,5trimethoxygeraniin, grandisines, rudrakine and flavonoids such as quercetin (Nain et al, 2012). The qualitative and quantitative phytochemical examination of the ethanolic fruit extract of the medicinally important plant, E. ganitrus revealed the presence of varied bioactive constituents such as alkaloids, glycosides, phenolic compounds, steroids, flavonoids, saponins, carbohydrates, and fixed oils (Hardainiyan et al, 2015). Phytochemical investigations of E. Ganitrus leaves bark and fruit displayed the presence of active principles such as alkaloids, tannins, and flavonoids.…”

Biological activities of phenolic compounds extracted from some plant species from east Kalimantan province, Indonesia

“…A report revealed about the activity of E. sylvestris leaf methanol extract with low of IC 50 value (74.4 ± 0.9 µg/mL) in the reaction of the pNPG substrate (Prihantini, Tachibana, & Itoh, 2014). Dried fruit of E. ganitrus (another related species) is also used for wound healing of Ayurveda treatment (Hardainiyan, Nandy, & Saxena, 2015). Interestingly, this is the first scientific report of Elaeocarpus species.…”