Purpose:Recurrent respiratory infection, diarrhoea etc. are the most common causes of morbidity in immune compromised children. Majority of children below the age of 5 years do get 7–8 episodes of cold per year. In developing countries about 15 million children under the age of 5 years die each year. Respiratory infection account for 4 million of deaths. In India 15% of death occurs during infancy and 1–5 years of age are due to respiratory infections. This statistic shows that children are more vulnerable to infection because their immune system is less or under developed. At this age any intervention which could motivate their immune system, may prove boon to them. Ayurveda with its concept of Rasayana is holding various medicinal plants which are excellent immunomodulator and capable to reduce the morbidity status.Method:Peer review journals were searched to list all medicinal plants with immunomodulator activities, particularly acting on recurrent respiratory infection and recurrent diarrhoeal episodes. Only full texts in English were accepted for the present study.Result:Out of all research Yashtimadhu (Glycyrrhiza glabra) was found potent to reduce morbidity rate. It is very cost effective, easily available with highest immunomodulator properties.Conclusion:Review suggests there are studies which confirms immunomodulatory effect of Yashtimadhu but recommend further extensive study.
Depression is a widespread psychiatric disorder affecting around 5% population of the world. It is fourth leading cause of disease trouble universal by ranked and it is expected to turn into the second most immobilizing disorder. Moreover, it is not easy to expect which patient will retort to whichever given treatment. At present obtainable antidepressant drugs are effective and harmless, but limitations range from a delayed start of action t o a considerable rate of non-responders. In the systems of traditional medicine, numerous plants and formulations have been used to take care of depression for thousands of years. We have reported antidepressant activity of EG. Therefore, the present study was start to evaluate the antidepressant potential of fruit extract of Elaeocarpus ganitrus and fraction of Elaeocarpus ganitrus in forced swim test (FST) and tail suspension test (TST). The mice were divided into six groups, each group containing five animals. Test drug Elaeocarpus ganitrus (EG) were suspended in distilled water. The vehicle (10ml/kg, p.o), Imipramine HCl (10mg/kg, p.o), EGE and EGF (50mg/kg, 100mg/kg, 150mg/kg and 200mg/kg, p.o. respectively) were administered 1 hour prior to study. Duration of immobility was noted in both the models. In our study, Imipramine HCl, EGE and EGF significantly reduced the duration of immobility in both experimental models as compared to the animals in the control gr oup. The antidepressant activity of EGE and EGF were comparable to that of standard drug Imipramine HCl. The results of the present study indicate the potential for use of EG as an adjuvant in the treatment of depression.
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