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transfected cells was associated with down-regulation of TRP ion channel expression. Finally, we demonstrated that TGF-b/SMAD signaling augments the development of MKs derived from CB-CD34 +. Present data suggest that RUNX1/TGF-b pathway cross talk is crucial for MK maturation.

In recent years, fabrication of AgNPs via plant extracts has gained much attention because of being environmentally friendly, non-hazardous and cost effective. The bio-fabrication of AgNPs using plant extracts as reducing, capping and stabilizing agents includes simpler, safer, less-toxic and energy efficient. AgNPs have been widely applied in numerous fields due to their bio-compatibility, multifunctionality, solubility, high stability, therapeutic and adhesive properties. This review focuses on the advantages of AgNPs synthesis using plant extracts and its applications in various fields for the betterment of mankind and environment with numerous examples and also highlights on explaining possible fundamental mechanisms involved in antimicrobial and anticancer activities of plant extract synthesized AgNPs.

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Major breakthroughs in the last several decades have contributed to our knowledge of the genetic regulation in development. Although epigenetics is not a new concept, unfortunately, the role of epigenetics has not come to fruition in the past. But the field of epigenetics has exploded within the past decade. Now, growing evidences show a complex network of epigenetic regulation in development. The epigenetic makeup of a cell, tissue or individual is much more complex than their genetic complement. Epigenetic modifications are more important for normal development by maintaining the gene expression pattern in tissue- and context-specific manner. Deregulation of epigenetic mechanism can lead to altered gene expression and its function, which result in altered tissue specific function of cells and malignant transformation. Epigenetic modifications directly shape Hematopoietic Stem Cell (HSC) developmental cascades, including their maintenance of self-renewal and multilineage potential, lineage commitment, and aging. Hence, there is a growing admiration for epigenetic players and their regulatory function in haematopoiesis. Epigenetic mechanisms underlying these modifications in mammalian genome are still not completely understood. This review mainly explains 3 key epigenetics mechanisms including DNA methylation, histone modifications and non-coding RNAs inference in hematopoietic lineage commitment and differentiation.

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